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mocarhagin

National Institutes of Health

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Metalloendopeptidases

Papers overview

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2013
2013
Chapter 243 – Mocarhagin
2006
2006
Molecular characterization of a human monoclonal antibody that interacts with a sulfated tyrosine-containing epitope of the GPIb receptor and inhibits platelet functions.
2005
2005
Translocation of GPIb and Fc receptor γ‐chain to cytoskeleton in mucetin‐activated platelets
Summary.  Recent studies have implied that GPIb‐IX‐V as well as functioning as an adhesion receptor may also induce signaling to… 
2004
2004
Snake venom toxins affecting platelet function.
Botrocetin from the South American pit viper Bothrops jararaca was described as an activator of von Willebrand factor-dependent… 
2004
2004
Thrombin binding to GPIbalpha induces integrin alphaIIbbeta3 dependent platelet adhesion to fibrin in ex vivo flowing whole blood.
We have investigated the role of the thrombin/GPIbalpha interaction in the adhesion of platelets to fibrin in a whole blood ex… 
2004
2004
Thrombin binding to GPIbα induces integrin αIIbβ3 dependent platelet adhesion to fibrin in ex vivo flowing whole blood
Summary We have investigated the role of the thrombin/GPIbα interaction in the adhesion of platelets to fibrin in a whole blood… 
2001
2001
Tonsillar B Cells Do Not Express PSGL-1, but a Significant Fraction Displays the Cutaneous Lymphocyte Antigen and Exhibits Effective E- and P-Selectin Ligand Activity
Skin-homing T cells are defined by the expression of the cutaneous lymphocyte-associated antigen (CLA) which enables the cells to… 
Highly Cited
2000
Highly Cited
2000
The Asp272–Glu282 Region of Platelet Glycoprotein Ibα Interacts with the Heparin-binding Site of α-Thrombin and Protects the Enzyme from the Heparin-catalyzed Inhibition by Antithrombin III*
Platelet glycoprotein Ib (GpIb) mediates interaction with both von Willebrand factor and thrombin. Thrombin binds to GpIb via its… 
2000
2000
The Asp(272)-Glu(282) region of platelet glycoprotein Ibalpha interacts with the heparin-binding site of alpha-thrombin and protects the enzyme from the heparin-catalyzed inhibition by antithrombin…
Platelet glycoprotein Ib (GpIb) mediates interaction with both von Willebrand factor and thrombin. Thrombin binds to GpIb via its… 
Highly Cited
1996
Highly Cited
1996
Mocarhagin, a novel cobra venom metalloproteinase, cleaves the platelet von Willebrand factor receptor glycoprotein Ibalpha. Identification of the sulfated tyrosine/anionic sequence Tyr-276-Glu-282…
Platelet adhesion to the subendothelium is the initiating event in hemostasis and thrombosis and involves the binding of von… 
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