mitochondrial unfolded protein response

Known as: mtUPR 
The series of molecular signals generated as a consequence of the presence of unfolded proteins in the mitochondrial matrix; results in… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2004-2017
0204020042017

Papers overview

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2016
2016
Neurons have a central role in the systemic coordination of mitochondrial unfolded protein response (UPRmt) and the cell non… (More)
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2015
2015
Proteostasis is crucial for life and maintained by cellular chaperones and proteases. One major mitochondrial protease is the… (More)
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2014
2014
The mitochondria of cancer cells are characterized by elevated oxidative stress caused by reactive oxygen species (ROS). Such an… (More)
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Highly Cited
2013
Highly Cited
2013
Longevity is regulated by a network of closely linked metabolic systems. We used a combination of mouse population genetics and… (More)
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2013
2013
Statins are cholesterol-lowering drugs that inhibit 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase, the rate-limiting enzyme… (More)
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Highly Cited
2007
Highly Cited
2007
The cellular response to unfolded and misfolded proteins in the mitochondrial matrix is poorly understood. Here, we report on a… (More)
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Highly Cited
2007
Highly Cited
2007
In an accompanying paper, we show that the mitochondrial Unfolded Protein Response or mtUPR is initiated by the activation of… (More)
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Highly Cited
2007
Highly Cited
2007
We have previously reported on the discovery of a mitochondrial specific unfolded protein response (mtUPR) in mammalian cells, in… (More)
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Highly Cited
2006
Highly Cited
2006
Perturbation of the protein-folding environment in the mitochondrial matrix selectively upregulates the expression of nuclear… (More)
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Highly Cited
2004
Highly Cited
2004
Protein folding in the mitochondria is assisted by nuclear-encoded compartment-specific chaperones but regulation of the… (More)
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