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mitochondrial outer membrane fusion

The membrane organization process that joins two mitochondrial outer membranes to form a single membrane. [GOC:vw, PMID:21385840]
National Institutes of Health

Topic mentions per year

Topic mentions per year

2011-2017
01220112017

Papers overview

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2017
2017
Involvement of mitochondrial dynamics in the antineoplastic activity of cisplatin in murine leukemia L1210 cells.
Leukemia is a type of hematopoietic stem cell malignant cloned disease with high mortality. Cisplatin-based chemotherapy is one… (More)
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2017
2017
SLP-2: a potential new target for improving mitochondrial function in Parkinson's disease
Parkinson’s disease (PD) is a progressive neurodegenerative disease, which is generally considered a multifactorial disorder that… (More)
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2016
2016
Mitochondrial fusion: Reaching the end of mitofusin’s tether
In this issue, Qi et al. (2016. J. Cell Biol https://doi.org/10.1083/jcb.201609019) provide structural insights into the… (More)
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2015
2015
MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons.
Mitochondrial dysfunction plays a central role in glutamate-evoked neuronal excitotoxicity, and mitochondrial fission/fusion… (More)
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Highly Cited
2014
Highly Cited
2014
Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation.
Mitochondrial fusion is essential for maintenance of mitochondrial function. The mitofusin GTPases control mitochondrial outer… (More)
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2013
2013
A uvs-5 strain is deficient for a mitofusin gene homologue, fzo1, involved in maintenance of long life span in Neurospora crassa.
Mitochondria are highly dynamic organelles that continuously fuse and divide. To maintain mitochondria, cells establish an… (More)
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Highly Cited
2012
Highly Cited
2012
Mitofusin 2-containing mitochondrial-reticular microdomains direct rapid cardiomyocyte bioenergetic responses via interorganelle Ca(2+) crosstalk.
RATIONALE Mitochondrial Ca(2+) uptake is essential for the bioenergetic feedback response through stimulation of Krebs cycle… (More)
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Highly Cited
2012
Highly Cited
2012
Stress-induced phosphorylation and proteasomal degradation of mitofusin 2 facilitates mitochondrial fragmentation and apoptosis.
Mitochondria play central roles in integrating pro- and antiapoptotic stimuli, and JNK is well known to have roles in activating… (More)
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2011
2011
Ugo1 and Mdm30 act sequentially during Fzo1-mediated mitochondrial outer membrane fusion.
Dynamin-related GTPase proteins (DRPs) are main players in membrane remodelling. Conserved DRPs called mitofusins (Mfn1/Mfn2/Fzo1… (More)
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2011
2011
Sequential requirements for the GTPase domain of the mitofusin Fzo1 and the ubiquitin ligase SCFMdm30 in mitochondrial outer membrane fusion.
The ability of cells to respire requires that mitochondria undergo fusion and fission of their outer and inner membranes. The… (More)
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