mitochondrial membrane permeabilization
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The present work demonstrates the ability of CO to prevent apoptosis in a primary culture of astrocytes. For the first time, the… Expand Mitochondria-associated ER membranes, or MAMs, define the sites of endoplasmic reticulum/mitochondria juxtaposition that control… Expand Irrespective of the morphological features of end-stage cell death (that may be apoptotic, necrotic, autophagic, or mitotic… Expand Mitochondrial membrane permeabilization (MMP) is considered as the “point-of-no-return” in numerous models of programmed cell… Expand Hydroxychloroquine (HCQ) is a lysosomotropic amine with cytotoxic properties. Here, we show that HCQ induces signs of lysosomal… Expand A number of diseases are due to lysosomal destabilization, which results in damaging cell loss. To investigate the mechanisms of… Expand One of the mechanisms by which chemotherapeutics destroy cancer cells is by inducing apoptosis. Apoptosis can be activated… Expand The dysregulation of programmed cell death (apoptosis) is involved in different pathologies including cancer, which is frequently… Expand Nuclear DNA damage and ligation of plasma-membrane death receptors have long been recognized as initial triggers of apoptosis… Expand Viral protein R (Vpr), an apoptogenic accessory protein encoded by HIV-1, induces mitochondrial membrane permeabilization (MMP… Expand