mitochondrial membrane permeability transition
National Institutes of Health
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Background: The induction of the mitochondrial membrane permeability transition (MMPT) pore has been implicated in the cascade of…
Purpose Dissipation of the electrochemical gradient across the inner mitochondrial membrane results in mitochondrial membrane…
Purpose Loss of integrity of either the inner or outer mitochondrial membrane results in the dissipation of the mitochondrial…
Oxidative stress is involved in the pathogenesis and progression of different liver diseases, such as alcoholic liver disease and…
Hydrophobic bile acids may cause hepatocellular necrosis and apoptosis during cholestatic liver diseases. The mechanism for this…
The ability of nonsteroidal anti-inflammatory drugs (NSAIDs) to induce Ca(2+)-mediated/cyclosporin A-sensitive mitochondrial…
Although ceramide signaling pathways have been implicated in cell death, neither their role in hepatocellular death nor the…
BACKGROUND & AIMS
The mitochondrial membrane permeability transition (MMPT) has been proposed as a mechanism of cell necrosis. In…
Ursodeoxycholate (UDCA), a hydrophilic bile salt, ameliorates hepatocellular injury by toxic bile salts and is used to treat…