migrastatin

 
National Institutes of Health

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Broader (2)

MacrolidesPiperidones

Papers overview

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Highly Cited
2011
Highly Cited
2011
Migrastatin analogues target fascin to block tumour metastasis
This corrects the article DOI: 10.1038/nature08978 
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2011
2011
Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin.
Migrastatin is a biologically active natural product isolated from Streptomyces that has been shown to inhibit tumor cell… (More)
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Highly Cited
2010
Highly Cited
2010
Inhibition of Eukaryotic Translation Elongation by Cycloheximide and Lactimidomycin
Although the protein synthesis inhibitor cycloheximide (CHX) has been known for decades, its precise mechanism of action remains… (More)
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2009
2009
Engineered production of iso-migrastatin in heterologous Streptomyces hosts.
Glutarimide-containing polyketides such as migrastatin (MGS) are well known for their ability to inhibit tumor cell migration. We… (More)
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2009
2009
iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide…
iso-Migrastatin and related glutarimide-containing polyketides are potent inhibitors of tumor cell migration and their implied… (More)
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2008
2008
Migrastatin and analogues: New anti-metastatic agents
Migrastatin and some migrastatin analogues are potent anti-metastatic agents. The biological activity as well as the chemical… (More)
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2005
2005
Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice.
Tumor metastasis is the most common cause of death in cancer patients. Here, we show that two, fully synthetic migrastatin… (More)
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2005
2005
Iso-migrastatin congeners from Streptomyces platensis and generation of a glutarimide polyketide library featuring the dorrigocin, lactimidomycin, migrastatin, and NK30424 scaffolds.
Iso-Migrastatin (10) has been shown to be the main natural product of Streptomyces platensis, which undergoes a facile, H2O… (More)
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2004
2004
Discovery of potent cell migration inhibitors through total synthesis: lessons from structure-activity studies of (+)-migrastatin.
Synthesis of highly active migrastatin-based tumor migration cell inhibitors has been accomplished. Our flexible and concise… (More)
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2004
2004
The migrastatin family: discovery of potent cell migration inhibitors by chemical synthesis.
The first asymmetric total synthesis of (+)-migrastatin (1), a macrolide natural product with anti-metastatic properties, has… (More)
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