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migrastatin
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Macrolides
Piperidones
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Migrastatin analogues target fascin to block tumour metastasis
Lin Chen
,
S. Yang
,
J. Jakoncic
,
J. Zhang
,
X. Huang
Nature
2011
Corpus ID: 4322681
This corrects the article DOI: 10.1038/nature08978
Highly Cited
2010
Highly Cited
2010
Inhibition of Eukaryotic Translation Elongation by Cycloheximide and Lactimidomycin
Tilman Schneider-Poetsch
,
J. Ju
,
+6 authors
J. Liu
Nature chemical biology
2010
Corpus ID: 17756831
Although the protein synthesis inhibitor cycloheximide (CHX) has been known for decades, its precise mechanism of action remains…
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Highly Cited
2010
Highly Cited
2010
Migrastatin Analogues Target Fascin to Block Tumor Metastasis
Lin Chen
,
S. Yang
,
J. Jakoncic
,
J. Zhang
,
X. Huang
Nature
2010
Corpus ID: 4397670
Tumour metastasis is the primary cause of death of cancer patients. Development of new therapeutics preventing tumour metastasis…
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2009
2009
Engineered production of iso-migrastatin in heterologous Streptomyces hosts.
Zhiyang Feng
,
L. Wang
,
S. Rajski
,
Z. Xu
,
Marie F Coeffet-LeGal
,
B. Shen
Bioorganic & medicinal chemistry
2009
Corpus ID: 5761329
Glutarimide-containing polyketides such as migrastatin (MGS) are well known for their ability to inhibit tumor cell migration. We…
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2009
2009
iso-Migrastatin, Migrastatin, and Dorrigocin Production in Streptomyces platensis NRRL 18993 Is Governed by a Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide…
Si-Kyu Lim
,
J. Ju
,
+7 authors
B. Shen
The Journal of Biological Chemistry
2009
Corpus ID: 5055082
iso-Migrastatin and related glutarimide-containing polyketides are potent inhibitors of tumor cell migration and their implied…
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Highly Cited
2005
Highly Cited
2005
Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice.
Dandan Shan
,
Lin Chen
,
+4 authors
X. Huang
Proceedings of the National Academy of Sciences…
2005
Corpus ID: 24735814
Tumor metastasis is the most common cause of death in cancer patients. Here, we show that two, fully synthetic migrastatin…
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Highly Cited
2004
Highly Cited
2004
Discovery of potent cell migration inhibitors through total synthesis: lessons from structure-activity studies of (+)-migrastatin.
J. T. Njardarson
,
Christoph Gaul
,
Dandan Shan
,
X. Huang
,
S. Danishefsky
Journal of the American Chemical Society
2004
Corpus ID: 27474837
Synthesis of highly active migrastatin-based tumor migration cell inhibitors has been accomplished. Our flexible and concise…
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Highly Cited
2004
Highly Cited
2004
The migrastatin family: discovery of potent cell migration inhibitors by chemical synthesis.
Christoph Gaul
,
J. T. Njardarson
,
+6 authors
S. Danishefsky
Journal of the American Chemical Society
2004
Corpus ID: 20686200
The first asymmetric total synthesis of (+)-migrastatin (1), a macrolide natural product with anti-metastatic properties, has…
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Highly Cited
2003
Highly Cited
2003
The total synthesis of (+)-migrastatin.
Christoph Gaul
,
J. T. Njardarson
,
S. Danishefsky
Journal of the American Chemical Society
2003
Corpus ID: 22776006
The first total synthesis of (+)-migrastatin, a macrolide natural product with interesting antimetastatic properties, has been…
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Highly Cited
2002
Highly Cited
2002
Migrastatin and a new compound, isomigrastatin, from Streptomyces platensis.
Elaine J. Woo
,
C. Starks
,
+4 authors
P. Licari
The Journal of antibiotics
2002
Corpus ID: 27337812
Streptomyces platensis (strain NRRL 18993), a producer of dorrigocins, was shown to produce migrastatin, a cyclic congener of…
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