migrastatin

This corrects the article DOI: 10.1038/nature08978 

Although the protein synthesis inhibitor cycloheximide (CHX) has been known for decades, its precise mechanism of action remains… Expand

Tumour metastasis is the primary cause of death of cancer patients. Development of new therapeutics preventing tumour metastasis… Expand

Glutarimide-containing polyketides such as migrastatin (MGS) are well known for their ability to inhibit tumor cell migration. We… Expand

iso-Migrastatin and related glutarimide-containing polyketides are potent inhibitors of tumor cell migration and their implied… Expand

Tumor metastasis is the most common cause of death in cancer patients. Here, we show that two, fully synthetic migrastatin… Expand

Synthesis of highly active migrastatin-based tumor migration cell inhibitors has been accomplished. Our flexible and concise… Expand

The first asymmetric total synthesis of (+)-migrastatin (1), a macrolide natural product with anti-metastatic properties, has… Expand

The first total synthesis of (+)-migrastatin, a macrolide natural product with interesting antimetastatic properties, has been… Expand

Streptomyces platensis (strain NRRL 18993), a producer of dorrigocins, was shown to produce migrastatin, a cyclic congener of… Expand