methylbenzoprim

Known as: 2,4-Pyrimidinediamine, 6-ethyl-5-(4-(methyl(phenylmethyl)amino)-3-nitrophenyl)- 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2016
01219902016

Papers overview

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2016
2016
BACKGROUND The antimalarial drug Pyrimethamine has been suggested to exert an antitumor activity by inducing apoptotic cell death… (More)
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2004
2004
Benzimidazole-N-oxide modifications of potent lipophilic dihydrofolate reductase (DHFR) inhibitors (e.g., methylbenzoprim 1 and… (More)
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2001
2001
Dichlorobenzoprim and methylbenzoprim were the lead compounds to emerge from investigations on a series of lipophilic 2,4-diamino… (More)
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1998
1998
We have synthesised a series of fluorescent analogues of methylbenzoprim, a diaminopyrimidine antifolate which we have previously… (More)
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1997
1997
Twelve novel 2,4-diamino-5-(4'-benzylamino)- and 2,4-diamino-5[4'-(N-methylbenzylamino)-3'-nitrophenyl]-6-ethylp yrimidines… (More)
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1992
1992
Methylbenzoprim (MBP) is a potent inhibitor of dihydrofolate reductase, which is more selective for mammalian than bacterial… (More)
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1992
1992
Methylbenzoprim and ethylbenzoprim undergo debenzylation in hydrochloric acid. Two reaction mechanisms are proposed to explain… (More)
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1990
1990
The new lipophilic dihydrofolate reductase inhibitor methylbenzoprim is a flexible substituted 2,4-diamino-5-arylpyrimidine… (More)
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1990
1990
1H and 19F NMR signals from bound ligands have been assigned in one- and two-dimensional NMR spectra of complexes of… (More)
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