Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

methylbenzoprim

Known as: 2,4-Pyrimidinediamine, 6-ethyl-5-(4-(methyl(phenylmethyl)amino)-3-nitrophenyl)- 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
BackgroundThe antimalarial drug Pyrimethamine has been suggested to exert an antitumor activity by inducing apoptotic cell death… Expand
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 4
Is this relevant?
2004
2004
Benzimidazole-N-oxide modifications of potent lipophilic dihydrofolate reductase (DHFR) inhibitors (e.g., methylbenzoprim 1 and… Expand
Is this relevant?
2001
2001
Dichlorobenzoprim and methylbenzoprim were the lead compounds to emerge from investigations on a series of lipophilic 2,4-diamino… Expand
Is this relevant?
1998
1998
We have synthesised a series of fluorescent analogues of methylbenzoprim, a diaminopyrimidine antifolate which we have previously… Expand
Is this relevant?
1997
1997
Twelve novel 2,4-diamino-5-(4'-benzylamino)- and 2,4-diamino-5[4'-(N-methylbenzylamino)-3'-nitrophenyl]-6-ethylp yrimidines… Expand
Is this relevant?
1992
1992
Methylbenzoprim (MBP) is a potent inhibitor of dihydrofolate reductase, which is more selective for mammalian than bacterial… Expand
Is this relevant?
1992
1992
Methylbenzoprim and ethylbenzoprim undergo debenzylation in hydrochloric acid. Two reaction mechanisms are proposed to explain… Expand
Is this relevant?
1990
1990
1H and 19F NMR signals from bound ligands have been assigned in one- and two-dimensional NMR spectra of complexes of… Expand
Is this relevant?
1990
1990
The new lipophilic dihydrofolate reductase inhibitor methylbenzoprim is a flexible substituted 2,4-diamino-5-arylpyrimidine… Expand
Is this relevant?