methylacetylphosphonate

Known as: phosphonoacetic acid, 1-methyl ester, methyl acetylphosphonate, methyl phosphonoacetaldehyde 
 
National Institutes of Health

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Phosphonoacetic Acid
analogs & derivatives

Papers overview

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2013
2013
Alternating sites reactivity is a common feature of thiamin diphosphate-dependent enzymes as evidenced by isothermal titration calorimetry studies of substrate binding.
Thiamin diphosphate (ThDP)-dependent enzymes play vital roles in cellular metabolism in all kingdoms of life. In previous kinetic… (More)
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2013
2013
Revisiting the biosynthesis of dehydrophos reveals a tRNA-dependent pathway.
Bioactive natural products containing a C-P bond act as mimics of phosphate esters and carboxylic acids, thereby competing with… (More)
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2012
2012
Glyoxylate carboligase: a unique thiamin diphosphate-dependent enzyme that can cycle between the 4'-aminopyrimidinium and 1',4'-iminopyrimidine tautomeric forms in the absence of the conserved…
Glyoxylate carboligase (GCL) is a thiamin diphosphate (ThDP)-dependent enzyme, which catalyzes the decarboxylation of glyoxylate… (More)
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2010
2010
Communication between thiamin cofactors in the Escherichia coli pyruvate dehydrogenase complex E1 component active centers: evidence for a "direct pathway" between the 4'-aminopyrimidine N1' atoms.
Kinetic, spectroscopic, and structural analysis tested the hypothesis that a chain of residues connecting the 4'-aminopyrimidine… (More)
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2009
2009
Multiple roles of mobile active center loops in the E1 component of the Escherichia coli pyruvate dehydrogenase complex - Linkage of protein dynamics to catalysis.
The region encompassing residues 401-413 on the E1 component of the pyruvate dehydrogenase multienzyme complex from Escherichia… (More)
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2006
2006
Direct kinetic evidence for half-of-the-sites reactivity in the E1 component of the human pyruvate dehydrogenase multienzyme complex through alternating sites cofactor activation.
Recent kinetic and structural studies on various thiamin-dependent enzymes, including the bacterial E1 component of the pyruvate… (More)
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2005
2005
Anion binding and controlled aggregation of human interleukin-1 receptor antagonist.
Highly concentrated human recombinant interleukin-1 receptor antagonist (IL-1ra) aggregates at elevated temperature without… (More)
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1992
1992
The functional, oxygen-linked chloride binding sites of hemoglobin are contiguous within a channel in the central cavity.
Chloride ion is a major allosteric regulator for many hemoglobins and particularly for bovine hemoglobin. A site-directed reagent… (More)
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1989
1989
Methyl acetyl phosphate as a covalent probe for anion-binding sites in human and bovine hemoglobins.
An allosteric modulator of oxygen release in human erythrocytes is 2,3-diphosphoglycerate, but bovine erythrocytes apparently… (More)
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1980
1980
Phosphonate analogues of pyruvate. Probes of substrate binding to pyruvate oxidase and other thiamin pyrophosphate-dependent decarboxylases.
A number of enzymes catalyze the removal of carbon dioxide from pyruvate through covalent participation of the coenzyme thiamin… (More)
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