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methotrexate transport

The directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of or within a cell, or between cells, by means of some agent such as… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
PurposeTo elucidate the role of the renal basolateral transporter, Oat3, in the disposition of methotrexate.Materials and… Expand
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Highly Cited
2004
Highly Cited
2004
Human organic anion transporters hOAT1 (SLC22A6) and hOAT3 (SLC22A8) are responsible for renal tubular secretion of an antifolic… Expand
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Highly Cited
2003
Highly Cited
2003
Overexpression of the ATP-binding cassette transporter ABCG2 reportedly causes multidrug resistance, whereas altered drug… Expand
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Highly Cited
2002
Highly Cited
2002
Life-threatening drug interactions are known to occur between methotrexate and nonsteroidal anti-inflammatory drugs (NSAIDs… Expand
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Highly Cited
2001
Highly Cited
2001
The ATP-binding cassette (ABC) proteins comprise a large superfamily of transmembrane transporters that utilize the energy of ATP… Expand
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Highly Cited
1995
Highly Cited
1995
This report describes the isolation, nucleotide sequencing, and functional expression of human cDNAs that restore reduced folate… Expand
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1995
1995
A retrospective study of clinical resistance to methotrexate (MTX) was performed on 29 archival specimens of frozen lymphoblasts… Expand
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1987
1987
We have studied the frequency of transport mutations in methotrexate-resistant Chinese hamster ovary cells using a rapid-flow… Expand
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1985
1985
A human T-lymphoblast cell line, CCRF-CEM/R1, resistant to methotrexate by virtue of increased dihydrofolate reductase activity… Expand
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Highly Cited
1968
Highly Cited
1968
Abstract Transport of methotrexate (4-amino-10-methylpteroyl-glutamic acid), a structural analogue of folic acid, was studied in… Expand
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