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methotrexate transport
The directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of or within a cell, or between cells, by means of some agent such as…
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National Institutes of Health
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Highly Cited
2004
Highly Cited
2004
Methotrexate-loxoprofen interaction: involvement of human organic anion transporters hOAT1 and hOAT3.
Y. Uwai
,
R. Taniguchi
,
Hideyuki Motohashi
,
H. Saito
,
M. Okuda
,
K. Inui
Drug Metabolism and Pharmacokinetics
2004
Corpus ID: 45142181
Human organic anion transporters hOAT1 (SLC22A6) and hOAT3 (SLC22A8) are responsible for renal tubular secretion of an antifolic…
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Highly Cited
2003
Highly Cited
2003
A functional study on polymorphism of the ATP-binding cassette transporter ABCG2: critical role of arginine-482 in methotrexate transport.
Hideyuki Mitomo
,
R. Kato
,
+7 authors
T. Ishikawa
Biochemical Journal
2003
Corpus ID: 20958463
Overexpression of the ATP-binding cassette transporter ABCG2 reportedly causes multidrug resistance, whereas altered drug…
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Highly Cited
2002
Highly Cited
2002
Characterization of Methotrexate Transport and Its Drug Interactions with Human Organic Anion Transporters
M. Takeda
,
Suparat Khamdang
,
+5 authors
H. Endou
Journal of Pharmacology and Experimental…
2002
Corpus ID: 29259838
Life-threatening drug interactions are known to occur between methotrexate and nonsteroidal anti-inflammatory drugs (NSAIDs…
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Highly Cited
2001
Highly Cited
2001
Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity.
Ken-ichi Ito
,
C. Oleschuk
,
Chris Westlake
,
M. Vasa
,
R. Deeley
,
S. Cole
Journal of Biological Chemistry
2001
Corpus ID: 2661307
The ATP-binding cassette (ABC) proteins comprise a large superfamily of transmembrane transporters that utilize the energy of ATP…
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Highly Cited
1995
Highly Cited
1995
Elevated dihydrofolate reductase and impaired methotrexate transport as elements in methotrexate resistance in childhood acute lymphoblastic leukemia.
L. Matherly
,
J. Taub
,
+6 authors
A. Rosowsky
Blood
1995
Corpus ID: 1742703
A retrospective study of clinical resistance to methotrexate (MTX) was performed on 29 archival specimens of frozen lymphoblasts…
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Highly Cited
1995
Highly Cited
1995
Isolation of Human cDNAs That Restore Methotrexate Sensitivity and Reduced Folate Carrier Activity in Methotrexate Transport-defective Chinese Hamster Ovary Cells (*)
So C Wong
,
S. A. Proefke
,
A. Bhushan
,
L. Matherly
Journal of Biological Chemistry
1995
Corpus ID: 35148004
This report describes the isolation, nucleotide sequencing, and functional expression of human cDNAs that restore reduced folate…
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Highly Cited
1987
Highly Cited
1987
Identification of methotrexate transport deficiency in mammalian cells using fluoresceinated methotrexate and flow cytometry.
Y. Assaraf
,
Robert T. Schimke
Proceedings of the National Academy of Sciences…
1987
Corpus ID: 24467719
We have studied the frequency of transport mutations in methotrexate-resistant Chinese hamster ovary cells using a rapid-flow…
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Highly Cited
1985
Highly Cited
1985
Cytotoxic effects of folate antagonists against methotrexate-resistant human leukemic lymphoblast CCRF-CEM cell lines.
E. Mini
,
B. Moroson
,
Christine T. Franco
,
J. R. Bertino
Cancer Research
1985
Corpus ID: 25795186
A human T-lymphoblast cell line, CCRF-CEM/R1, resistant to methotrexate by virtue of increased dihydrofolate reductase activity…
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Highly Cited
1984
Highly Cited
1984
Synthesis and properties of 7-hydroxymethotrexate polyglutamyl derivatives in Ehrlich ascites tumor cells in vitro.
G. Fabre
,
I. Fabre
,
L. Matherly
,
J. Cano
,
I. Goldman
Journal of Biological Chemistry
1984
Corpus ID: 45641263
Highly Cited
1968
Highly Cited
1968
Carrier-mediated transport of the folic acid analogue, methotrexate, in the L1210 leukemia cell.
Norman
,
S. Lichtenstein
,
Vincent
,
T.
,
Oliverio
Journal of Biological Chemistry
1968
Corpus ID: 33084169
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