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methotrexate polyglutamate

Known as: Methotrexate polyglutamates, Poly(imino(1-carboxy-4-oxo-1,4-butanediyl)), alpha-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-omega-hydroxy-, (S)- 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (2)

MethotrexatePolyglutamic Acid
Methotrexate polyglutamates:Imp:Pt:RBC:NarMethotrexate polyglutamates:SCnc:Pt:RBC:Qnanalogs & derivatives

Narrower (1)

methotrexate triglutamate

Papers overview

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2001
2001
The association of the TEL-AML1 chromosomal translocation with the accumulation of methotrexate polyglutamates in lymphoblasts and with ploidy in childhood B-progenitor cell acute lymphoblastic…
Lymphoblasts from children with B-progenitor cell acute lymphoblastic leukemia (BpALL) with chromosomal hyperdiploidy and with… 
1993
1993
Retentiveness of methotrexate polyglutamates in cultured L1210 cells. Evidence against a role for mediated plasma membrane transport outward.
1992
1992
Facilitated transport of methotrexate polyglutamates into lysosomes derived from S180 cells. Further characterization and evidence for a simple mobile carrier system with broad specificity for homo…
Studies are presented further characterizing a facilitative system transporting methotrexate (MTX) polyglutamates into lysosomes… 
1991
1991
Evidence for the facilitated transport of methotrexate polyglutamates into lysosomes derived from S180 cells. Basic properties and specificity for polyglutamate chain length.
1988
1988
Proliferation-dependent cytotoxicity of methotrexate in murine L5178Y leukemia.
The basis for the proliferation-dependent cytotoxicity of methotrexate has been investigated in mice bearing the L5178Y ascites… 
Highly Cited
1986
Highly Cited
1986
Hydrolytic cleavage of methotrexate gamma-polyglutamates by folylpolyglutamyl hydrolase derived from various tumors and normal tissues of the mouse.
Folylpolyglutamate hydrolase (folyl hydrolase) activity derived from murine tumors and various normal tissues was measured by… 
1986
1986
Regulation of methotrexate polyglutaminate formation in Ehrlich ascites carcinoma cells by endogenous folate pool.
The conversion of methotrexate to poly-gamma-glutamyl derivatives in Ehrlich ascites carcinoma cells which are characterized by… 
1983
1983
Effects of folinic acid on hepatoma cells containing methotrexate polyglutamates.
The effects of folinic acid on a toxic pulse exposure of cultured hepatoma cells to methotrexate (4-amino-10… 
1983
1983
Studies of formation and efflux of methotrexate polyglutamates with cultured hepatic cells.
Methotrexate polyglutamates are extensively synthesized when cultured hepatocytes and H35 hepatoma cells are exposed to… 
1983
1983
Regulation of methotrexate polyglutamate accumulation in vitro: effects of cellular folate content.
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