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methionine sulfoxide (protein) reductase activity

Known as: peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (S)-S-oxide-forming] activity, methionine S-oxide reductase (S-form oxidizing) activity, peptide-methionine-(S)-S-oxide reductase activity 
Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine… Expand
National Institutes of Health

Related topics

Related topics

3 relations
MSRA geneProtein-methionine-S-oxide reductase

Broader (1)

methionine sulfoxide reductase activity

Papers overview

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Highly Cited
2010
Highly Cited
2010
Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups
Meta-analyses of population-based genome-wide association studies (GWAS) in adults have recently led to the detection of new… Expand
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Highly Cited
2009
Highly Cited
2009
Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution
To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide… Expand
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Review
2009
Review
2009
Functions and evolution of selenoprotein methionine sulfoxide reductases.
Methionine sulfoxide reductases (Msrs) are thiol-dependent enzymes which catalyze conversion of methionine sulfoxide to… Expand
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Highly Cited
2007
Highly Cited
2007
Free methionine-(R)-sulfoxide reductase from Escherichia coli reveals a new GAF domain function
The reduction of methionine sulfoxide (MetO) is mediated by methionine sulfoxide reductases (Msr). The MsrA and MsrB families can… Expand
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Review
2005
Review
2005
Macrophage activation in atherosclerosis: pathogenesis and pharmacology of plaque rupture.
Atherosclerosis is still an important disease. It accounts for 39% of deaths in the U.K. and 12 million U.S citizens have… Expand
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Highly Cited
2004
Highly Cited
2004
Methionine sulfoxide reductase A is important for lens cell viability and resistance to oxidative stress.
Age-related cataract, an opacity of the eye lens, is the leading cause of visual impairment in the elderly, the etiology of which… Expand
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Highly Cited
2001
Highly Cited
2001
Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals
Oxidation of proteins by reactive oxygen species is associated with aging, oxidative stress, and many diseases. Although free and… Expand
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Highly Cited
2001
Highly Cited
2001
Peptide methionine sulfoxide reductase from Escherichia coli and Mycobacterium tuberculosis protects bacteria against oxidative damage from reactive nitrogen intermediates
Inducible nitric oxide synthase (iNOS) plays an important role in host defense. Macrophages expressing iNOS release the reactive… Expand
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Highly Cited
1999
Highly Cited
1999
Decrease in peptide methionine sulfoxide reductase in Alzheimer's disease brain.
Previous studies have shown that the pathophysiology of Alzheimer's disease (AD) is linked to oxidative stress. Oxidative damage… Expand
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Highly Cited
1997
Highly Cited
1997
The yeast peptide-methionine sulfoxide reductase functions as an antioxidant in vivo.
A gene homologous to methionine sulfoxide reductase (msrA) was identified as the predicted ORF (cosmid 9379) in chromosome V of… Expand
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