FAQ

methionine sulfoxide (protein) reductase activity

Known as: peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (S)-S-oxide-forming] activity, methionine S-oxide reductase (S-form oxidizing) activity, peptide-methionine-(S)-S-oxide reductase activity 
Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1970-2017
0102019702017

Related topics

Related topics

3 relations
MSRA geneProtein-methionine-S-oxide reductase

Broader (1)

methionine sulfoxide reductase activity

Related mentions per year

Related mentions per year

1970-2018
197019801990200020102020
methionine sulfoxide (protein) reductase activity
Protein-methionine-S-oxide reductase
MSRA gene
methionine sulfoxide reductase activity

Papers overview

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Highly Cited
2010
Highly Cited
2010
Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups
Meta-analyses of population-based genome-wide association studies (GWAS) in adults have recently led to the detection of new… (More)
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2010
2010
Methionine sulfoxide reductase B1 (MsrB1) recovers TRPM6 channel activity during oxidative stress.
Mg(2+) is an essential ion for many cellular processes, including protein synthesis, nucleic acid stability, and numerous… (More)
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2009
2009
MsrB1 (methionine-R-sulfoxide reductase 1) knock-out mice: roles of MsrB1 in redox regulation and identification of a novel selenoprotein form.
Protein oxidation has been linked to accelerated aging and is a contributing factor to many diseases. Methionine residues are… (More)
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2008
2008
Analysis of methionine/selenomethionine oxidation and methionine sulfoxide reductase function using methionine-rich proteins and antibodies against their oxidized forms.
Methionine (Met) residues are present in most proteins. However, this sulfur-containing amino acid is highly susceptible to… (More)
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2007
2007
Elevated levels of brain-pathologies associated with neurodegenerative diseases in the methionine sulfoxide reductase A knockout mouse
One of the posttranslational modifications to proteins is methionine oxidation, which is readily reversible by the methionine… (More)
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Highly Cited
2004
Highly Cited
2004
Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging.
Aging is thought to be caused by the accumulation of damage, primarily from oxidative modifications of cellular components by… (More)
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2003
2003
Selenium-deficient diet enhances protein oxidation and affects methionine sulfoxide reductase (MsrB) protein level in certain mouse tissues.
Mammals contain two methionine sulfoxide (MetO) reductases, MsrA and MsrB, that catalyze the thioredoxin-dependent reduction of… (More)
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Highly Cited
2001
Highly Cited
2001
Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals.
Oxidation of proteins by reactive oxygen species is associated with aging, oxidative stress, and many diseases. Although free and… (More)
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Highly Cited
2001
Highly Cited
2001
Peptide methionine sulfoxide reductase from Escherichia coli and Mycobacterium tuberculosis protects bacteria against oxidative damage from reactive nitrogen intermediates.
Inducible nitric oxide synthase (iNOS) plays an important role in host defense. Macrophages expressing iNOS release the reactive… (More)
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Highly Cited
1997
Highly Cited
1997
The yeast peptide-methionine sulfoxide reductase functions as an antioxidant in vivo.
A gene homologous to methionine sulfoxide reductase (msrA) was identified as the predicted ORF (cosmid 9379) in chromosome V of… (More)
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