metalloendopeptidase inhibitor activity

Known as: metalloprotease inhibitor, metalloproteinase inhibitor 
Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1982-2018
0204019822018

Papers overview

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Highly Cited
2007
Highly Cited
2007
Matrix metalloproteinases (MMPs) disrupt the blood-brain barrier (BBB) during reperfusion. Occludin and claudins are recently… (More)
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Highly Cited
2003
Highly Cited
2003
OBJECTIVE Angiotensin II (AngII) infusion into hyperlipidemic mice leads to the rapid formation of atherosclerotic lesions and… (More)
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Highly Cited
2003
Highly Cited
2003
PURPOSE To compare the selective matrix metalloproteinase inhibitor BAY 12-9566 with the nucleoside analog gemcitabine in the… (More)
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Highly Cited
2002
Highly Cited
2002
Pancreatic cancer is the fifth most common cause of cancer death in the western world and the prognosis for unresectable disease… (More)
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Highly Cited
1996
Highly Cited
1996
Smooth muscle cell (SMC) migration and proliferation and extracellular matrix remodeling are essential aspects of the arterial… (More)
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Highly Cited
1994
Highly Cited
1994
We have characterized matrix metalloproteinase expression in the rat carotid artery after two forms of arterial injury, balloon… (More)
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Highly Cited
1994
Highly Cited
1994
Matrix metalloproteinases have been implicated in the growth and spread of metastatic tumors. This role was investigated in an… (More)
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Highly Cited
1993
Highly Cited
1993
We have examined the effect of a synthetic low-molecular-weight matrix metalloproteinase inhibitor, [4-(N-hydroxyamino)-2R… (More)
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Highly Cited
1993
Highly Cited
1993
Tissue inhibitor of metalloproteinase-2 (TIMP-2), a protease inhibitor that binds to the latent and active forms of 72 kDa type… (More)
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Highly Cited
1989
Highly Cited
1989
Cartilage specimens from tibial plateaus, obtained from 13 osteoarthritic (OA) patients and seven controls, were selected from… (More)
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