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melagatran
Known as:
N-((R)-(((2S)-2-((-p-amidobenzyl)carbamoyl)-1-azetidinyl)carbonyl)cyclohexylmethyl)glycine
National Institutes of Health
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Related topics
Related topics
3 relations
Broader (3)
Antithrombins
Azetidines
Benzylamines
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Hepatic Disposition of Ximelagatran and Its Metabolites in Pig; Prediction of the Impact of Membrane Transporters Through a Simple Disposition Model
E. Sjögren
,
U. Bredberg
,
+4 authors
H. Lennernäs
Pharmaceutical Research
2010
Corpus ID: 6655643
PurposeThe double prodrug, ximelagatran, is bioconverted, via the intermediates ethylmelagatran and N-hydroxymelagatran, to the…
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2008
2008
Hypercoagulability in rats is increased by low doses of the direct thrombin inhibitor melagatran, but is reduced by the direct Factor Xa inhibitor rivaroxaban
E. Perzborn
,
U. Buetehorn
,
E. Fischer
,
M. Harwardt
,
M. Klages
,
A. Trabandt
2008
Corpus ID: 74440494
85236 presented at the European Society of Cardiology (ESC) Congress 2008, Munich, Germany; 30 August–3 September 2008
Review
2007
Review
2007
New Anticoagulants
Job Harenberg1
,
Benito Casu2
Hematology. American Society of Hematology…
2007
Corpus ID: 25962132
Traditional anticoagulant drugs, including unfractionated heparin and warfarin, have several limitations. New anticoagulants have…
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2005
2005
Melagatran and ximelagatran: new drug. No real simplification of anticoagulant therapy.
Prescrire international
2005
Corpus ID: 22204122
(1) The reference drug for prophylaxis against venous thromboembolism after hip or knee replacement surgery is a low-molecular…
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Review
2005
Review
2005
Low Potential for Interactions Between Melagatran/Ximelagatran and Other Drugs, Food, or Alcohol
M. Wolzt1
,
Troy Sarich2
,
Ulf Eriksson3
Seminars in Vascular Medicine
2005
Corpus ID: 29660569
C
2005
2005
Ecarin Chromogenic Assay
U. Lange
,
A. Olschewski
,
G. Nowak
,
E. Bucha
Hämostaseologie
2005
Corpus ID: 72978804
Zusammenfassung Der ECA (ecarin chromogenic assay) wurde zur quantitativen Bestimmung von direkten Thrombininhibitoren entwickelt…
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Review
2004
Review
2004
Direct antithrombins: new perspectives in cardiovascular medicine.
M. Lettino
,
V. Toschi
Current Medicinal Chemistry - Cardiovascular…
2004
Corpus ID: 24339043
Thrombin converts fibrinogen to fibrin and is the most powerful activator of platelets thus playing a crucial role in arterial…
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2004
2004
Islet Xenotransplantation : An Experimental Study of Barriers to Clinical Transplantation
P. Schmidt
2004
Corpus ID: 29281552
In the field of transplantation, the increasing deficit of human donors have lead to an interest in animals as an alternative…
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2003
2003
Melagatran und Ximelagatran
G. Pindur
,
S. Ziegeler
,
P. D. S. Kleinschmidt
Der Anaesthesist
2003
Corpus ID: 30984724
ZusammenfassungMelagatran ist ein direkter Thrombininhibitor. Es handelt sich zusammen mit seiner peroral wirksamen Vorstufe…
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2003
2003
Chromogenes Substrat als Antidot gegen den Thrombininhibitor Melagatran?
I. Bodendiek
,
S. Lentz
,
M. Seeger
,
H. Bruhn
Hämostaseologie
2003
Corpus ID: 56676997
Zusammenfassung Mit In-vitro-Untersuchungen wird gezeigt, dass ein chromogenes Substrat (Chromozym TH von Roche, Mannheim) die…
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