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meiogynin A

National Institutes of Health

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2015
2015
Development of an efficient route toward meiogynin A-inspired dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins.
The synthesis, on a large scale, with very good yield and er via an efficient strategy, of a chiral 4-substituted 2-cyclohexenone… 
2014
2014
From meiogynin A to the synthesis of dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins.
The synthesis of one of the most potent dual inhibitors of the anti-apoptotic proteins Bcl-xL and Mcl-1 is reported. This… 
2014
2014
Pro-apoptotic meiogynin A derivatives that target Bcl-xL and Mcl-1.
2010
2010
Biomimetic total synthesis of meiogynin A, an inhibitor of Bcl-xL and Bak interaction.
A short, convergent, and selective synthesis of meiogynin A, an inhibitor of the antiapoptotic protein Bcl-xL, has been performed… 
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