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megazol

Known as: 2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4- thiadiazole 
National Institutes of Health

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Thiadiazoles

Papers overview

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2019
2019
Synthesis and Antitrypanosomal Profile of Novel Hydrazonoyl Derivatives.
BACKGROUND Approximately 5-7 million people are infected with T. cruzi in the world, and approximately 10,000 people per year die… 
2007
2007
Design, synthesis and activity against Trypanosoma cruzi of azaheterocyclic analogs of megazol.
This study describes the design, synthesis and trypanocidal evaluation of new azaheterocyclic derivatives (4-8). These compounds… 
2005
2005
Electrochemical Study of 4‐Substituted Analogues of Megazol
The electrochemical behavior of three different megazol analogues substituted at position 4 and their comparison with the parent… 
2001
2001
Polarographic Reduction of Megazol and Derivatives, and Its Polarographic, UV Spectrophotometric, and HPLC Determination
Megazol (2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazol, CAS 19622-55-0), a highly active compound used against… 
2001
2001
Cyclic voltammetric studies on nitro radical anion formation from megazol and some related nitroimidazole derivatives
Review
1998
Review
1998
[Human African trypanosomiasis, contributions of experimental models].
Melarsoprol has remained the chosen drug for the late-stage treatment of human African trypanosomiasis (HAT) due both to… 
1996
1996
Topical chemotherapy for experimental African trypanosomiasis with cerebral involvement: the use of melarsoprol combined with the 5‐nitroimidazole, megazol
Megazol, one of a number of related 5‐nitroimidazoles, can be dissolved in dimethylsulphoxide and the solution can be converted… 
1990
1990
Effect of the host specific treatment in the phagocytosis of Trypanosoma cruzi blood forms by mouse peritoneal macrophages.
Single doses of drugs active against Trypanosoma cruzi (megazol, nifurtimox and benznidazole) induce a rapid clearance of the… 
1989
1989
Restricted bioreductive metabolism of a nitroimidazole-thiadiazole derivative with curative action in experimental Trypanosoma cruzi infections.
1987
1987
Effect of drugs on Trypanosoma cruzi and on its interaction with heart muscle cell "in vitro".
Megazol, nifurtimox, benznidazol and allopurinol were investigated, by light and electron microscopy, for their action on T… 
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