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mavoglurant
National Institutes of Health
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AFQ056
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Integrated In Silico Fragment-Based Drug Design: Case Study with Allosteric Modulators on Metabotropic Glutamate Receptor 5
Yuemin Bian
,
Zhiwei Feng
,
Peng Yang
,
X. Xie
AAPS Journal
2017
Corpus ID: 255557175
GPCR allosteric modulators target at the allosteric binding pockets of G protein-coupled receptors (GPCRs) with indirect…
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2016
2016
Intravenous Dosing as an Alternate Approach to Safely Achieve Supratherapeutic Exposure for Assessments of Cardiac Repolarization: A Randomized Clinical Trial with Mavoglurant (AFQ056).
M. Ufer
,
A. Sagkriotis
,
+7 authors
E. Legangneux
Clinical Therapeutics
2016
Corpus ID: 5570456
2016
2016
The Challenge of Assessing Response to Psychotropic Medication Trials in Very Young Children with Fragile X Syndrome: A Cautionary Note.
D. Kelly
Journal of Developmental and Behavioral…
2016
Corpus ID: 38763641
Desmond Kelly, MD Fragile X syndrome (FXS) has been extensively researched and provides a very helpful model for the elucidation…
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2015
2015
Effect of mavoglurant (AFQ056), a selective mGluR5 antagonist, on the pharmacokinetics of a combined oral contraceptive containing ethinyl estradiol and levonorgestrel in healthy women.
R. Sivasubramanian
,
A. Chakraborty
,
+6 authors
M. Ufer
International journal of clinical pharmacology…
2015
Corpus ID: 7002355
OBJECTIVE To compare the pharmacokinetics (PKs) of a combination oral contraceptive (OC) when given alone or concomitantly with…
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2015
2015
Effect of mavoglurant (AFQ056) on the Pharmacokinetics of a combined oral contraceptive containing ethinyl estradiol and Levonorgestrel in healthy Women
R. Sivasubramanian
,
A. Chakraborty
,
+6 authors
M. Ufer
2015
Corpus ID: 78161456
2014
2014
Model-Based Evaluation of the Impact of Formulation and Food Intake on the Complex Oral Absorption of Mavoglurant in Healthy Subjects
Thierry Wendling
,
K. Ogungbenro
,
E. Pigeolet
,
Swati Dumitras
,
R. Woessner
,
L. Aarons
Pharmaceutical Research
2014
Corpus ID: 17762364
To compare the pharmacokinetics of intravenous (IV), oral immediate-release (IR) and oral modified-release (MR) formulations of…
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2014
2014
N03 Efficacy, Safety, And Tolerability Of Afq056 For The Treatment Of Chorea In Patients With Huntington’s Disease
R. Reilmann
,
Marie‐Laure Rouzade‐Dominguez
,
+10 authors
B. Gomez-Mancilla
Journal of Neurology Neurosurgery & Psychiatry
2014
Corpus ID: 76383995
Background Treatments of chorea in patients with HD have limited efficacy and side-effects. AFQ056, a selective metabotropic…
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2013
2013
PP245—In-vitro bioassay of 1,5 - dimethyl citrate monohydrate; a compound isolated from the fruit of mangifera Indica (anacardiaceae)
F. Khan
,
E. Olowononi
,
M. Garba
,
A. Lawal
2013
Corpus ID: 73353769
2013
2013
Metabolism and Disposition of the Metabotropic Glutamate Receptor 5 Antagonist ( mGluR 5 ) Mavoglurant ( AFQ 056 ) in Healthy Subjects
M. Walles
,
Thierry Wolf
,
+11 authors
P. Swart
2013
Corpus ID: 12947902
The disposition and biotransformation of C-radiolabeled mavoglurant were investigated in four healthy male subjects after a…
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