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mavoglurant

National Institutes of Health

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AFQ056

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Papers overview

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2017
2017
Integrated In Silico Fragment-Based Drug Design: Case Study with Allosteric Modulators on Metabotropic Glutamate Receptor 5
GPCR allosteric modulators target at the allosteric binding pockets of G protein-coupled receptors (GPCRs) with indirect… 
2016
2016
Intravenous Dosing as an Alternate Approach to Safely Achieve Supratherapeutic Exposure for Assessments of Cardiac Repolarization: A Randomized Clinical Trial with Mavoglurant (AFQ056).
2016
2016
The Challenge of Assessing Response to Psychotropic Medication Trials in Very Young Children with Fragile X Syndrome: A Cautionary Note.
Desmond Kelly, MD Fragile X syndrome (FXS) has been extensively researched and provides a very helpful model for the elucidation… 
2015
2015
Effect of mavoglurant (AFQ056), a selective mGluR5 antagonist, on the pharmacokinetics of a combined oral contraceptive containing ethinyl estradiol and levonorgestrel in healthy women.
OBJECTIVE To compare the pharmacokinetics (PKs) of a combination oral contraceptive (OC) when given alone or concomitantly with… 
2015
2015
Effect of mavoglurant (AFQ056) on the Pharmacokinetics of a combined oral contraceptive containing ethinyl estradiol and Levonorgestrel in healthy Women
2014
2014
Model-Based Evaluation of the Impact of Formulation and Food Intake on the Complex Oral Absorption of Mavoglurant in Healthy Subjects
To compare the pharmacokinetics of intravenous (IV), oral immediate-release (IR) and oral modified-release (MR) formulations of… 
2014
2014
N03 Efficacy, Safety, And Tolerability Of Afq056 For The Treatment Of Chorea In Patients With Huntington’s Disease
Background Treatments of chorea in patients with HD have limited efficacy and side-effects. AFQ056, a selective metabotropic… 
2013
2013
PP245—In-vitro bioassay of 1,5 - dimethyl citrate monohydrate; a compound isolated from the fruit of mangifera Indica (anacardiaceae)
2013
2013
Metabolism and Disposition of the Metabotropic Glutamate Receptor 5 Antagonist ( mGluR 5 ) Mavoglurant ( AFQ 056 ) in Healthy Subjects
The disposition and biotransformation of C-radiolabeled mavoglurant were investigated in four healthy male subjects after a… 
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