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mapracorat

National Institutes of Health

Papers overview

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2017
2017
Comparison of Occlusive and Open Application in a Psoriasis Plaque Test Design, Exemplarily Using Investigations of Mapracorat 0.1% Ointment versus Vehicle and Reference Drugs
Background/Aims: Psoriasis plaque tests (PPTs) are important tools in the early phases of antipsoriatic drug development. Two… 
Review
2015
Review
2015
Mapracorat, a novel non-steroidal selective glucocorticoid receptor agonist for the treatment of allergic conjunctivitis.
Glucocorticoids are used to treat chronic and severe forms of allergic conjunctivitis. Although they exert a rapid and powerful… 
2013
2013
Anti-allergic effects of mapracorat, a novel selective glucocorticoid receptor agonist, in human conjunctival fibroblasts and epithelial cells
Purpose To determine the ocular anti-allergic effects of mapracorat, a novel selective glucocorticoid receptor agonist (SEGRA) in… 
2013
2013
Induction of MAPK Phosphatase-1 by the Novel Selective Glucocorticoid Receptor Agonist Mapracorat Suppresses Inflammatory Signaling Pathways in Human Corneal Epithelial Cells
2013
2013
Comparison of effects between glucocorticoids and mapracorat after repeat topical ocular administration in rabbits for 28 days
Highly Cited
2011
Highly Cited
2011
In vivo ocular efficacy profile of mapracorat, a novel selective glucocorticoid receptor agonist, in rabbit models of ocular disease.
PURPOSE To compare the efficacy of mapracorat (formerly ZK-245186, and subsequently BOL-303242-X), a novel selective… 
2011
2011
Eosinophil as a cellular target of the ocular anti-allergic action of mapracorat, a novel selective glucocorticoid receptor agonist
Purpose Glucocorticoids can either suppress gene transcription (transrepression) or activate it (transactivation). This latter… 
2011
2011
Anti‐inflammatory mechanisms of mapracorat, a novel selective glucocorticoid receptor agonist, in human conjunctival fibroblasts
Purpose Mapracorat (BOL‐303242‐X; ZK 245186) is a selective glucocorticoid receptor agonist (SEGRA), under clinical evaluation… 
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