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lysyl-isoleucyl-phenylalanyl-methionyl-lysine

Known as: KIFMK, Lys-Ile-Phe-Met-Lys 
 
National Institutes of Health

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2 relations

Broader (2)

OligopeptidesSodium Channel Blockers

Papers overview

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2014
2014
Experimental design-guided development of a stereospecific capillary electrophoresis assay for methionine sulfoxide reductase enzymes using a diastereomeric pentapeptide substrate.
A capillary electrophoresis method has been developed and validated to evaluate the stereospecific activity of recombinant human… Expand
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2008
2008
Ryanoids and imperatoxin affect the modulation of cardiac ryanodine receptors by dihydropyridine receptor Peptide A.
Ca(2+)-entry via L-type Ca(2+) channels (DHPR) is known to trigger ryanodine receptor (RyR)-mediated Ca(2+)-release from… Expand
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2004
2004
Suppression of insulin signalling by a synthetic peptide KIFMK suggests the cytoplasmic linker between DIII-S6 and DIV-S1 as a local anaesthetic binding site on the sodium channel.
1. Acetyl-KIFMK-amide (KIFMK) restores fast inactivation to mutant sodium channels having a defective inactivation gate. Its… Expand
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2003
2003
Oligopeptide-mediated helix stabilization of model peptides in aqueous solution.
Oligopeptide-mediated helix stabilization of peptides in hydrophobic solutions was previously found by NMR and CD spectroscopic… Expand
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1999
1999
Block of Brain Sodium Channels by Peptide Mimetics of the Isoleucine, Phenylalanine, and Methionine (IFM) Motif from the Inactivation Gate
Inactivation of sodium channels is thought to be mediated by an inactivation gate formed by the intracellular loop connecting… Expand
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1999
1999
A human muscle Na+ channel mutation in the voltage sensor IV/S4 affects channel block by the pentapeptide KIFMK.
1. Whole cell patch clamping of transfected HEK293 cells was used to examine the effects of a pentapeptide (KIFMK) containing the… Expand
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Highly Cited
1998
Highly Cited
1998
A critical role for the S4-S5 intracellular loop in domain IV of the sodium channel alpha-subunit in fast inactivation.
Na+ channel fast inactivation is thought to involve the closure of an intracellular inactivation gate over the channel pore… Expand
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1998
1998
Kinetic Analysis of Block of Open Sodium Channels by a Peptide Containing the Isoleucine, Phenylalanine, and Methionine (IFM) Motif from the Inactivation Gate
We analyzed the kinetics of interaction between the peptide KIFMK, containing the isoleucine, phen-ylalanine, and methionine (IFM… Expand
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1997
1997
Competition for Binding Between Veratridine and KIFMK: An Open Channel Blocking Peptide of the RIIA Sodium Channel
Abstract. Veratridine, an alkaloid isolated from the rhizome of V. album, binds and slows the inactivation of the brain sodium… Expand
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1996
1996
Role of an S4-S5 linker in sodium channel inactivation probed by mutagenesis and a peptide blocker
A pair of conserved methionine residues, located on the cytoplasmic linker between segments S4 and S5 in the fourth domain of… Expand
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