lodamin

Chronic and recurrent uveitis account for approximately 10% of legal blindness in the western world. Autoimmune uveitis is driven… Expand

Lodamin, the oral formulation of TNP-470, a methionine aminopeptidase 2 (MetAp2) inhibitor, was previously shown to significantly… Expand

Endometriosis is a debilitating disease characterized by the growth of ectopic endometrial tissue. It is widely accepted that… Expand

Pathological neovascularization is a hallmark of late stage neovascular (wet) age-related macular degeneration (AMD) and the… Expand

Abstract : Centers on the development of new medical therapies and regenerative medicine approaches for the treatment of injured… Expand

Targeting angiogenesis, the formation of blood vessels, is an important modality for cancer therapy. TNP-470, a fumagillin analog… Expand

Despite promising early results, cancer therapy aimed at selective destruction of tumor blood vessels faces several hurdles… Expand

1118 Targeting angiogenesis, the formation of new blood vessels, is becoming an important strategy for cancer therapy. TNP-470… Expand

769 possibly breast cancers4,5. However, in most advanced tumors, the response to antiangiogenic therapy, even in combination… Expand

inhibitor TNP-470 is a potent suppressor of tumour growth and metastasis, but its use is limited because it requires lengthy… Expand