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lodamin

Known as: mPEG-PLA-TNP-470 
National Institutes of Health

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2 relations

Broader (2)

PolyestersSesquiterpenes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Suppression of Autoimmune Retinal Inflammation by an Antiangiogenic Drug
Chronic and recurrent uveitis account for approximately 10% of legal blindness in the western world. Autoimmune uveitis is driven… 
2013
2013
Abstract 2140: Oral antiangiogenic therapy suppresses xenograft growth and is well tolerated in rats.
Lodamin, the oral formulation of TNP-470, a methionine aminopeptidase 2 (MetAp2) inhibitor, was previously shown to significantly… 
Highly Cited
2011
Highly Cited
2011
Circulating Endothelial Progenitor Cells Are Up-Regulated in a Mouse Model of Endometriosis
2010
2010
Broad Spectrum Antiangiogenic Treatment for Ocular Neovascular Diseases
Pathological neovascularization is a hallmark of late stage neovascular (wet) age-related macular degeneration (AMD) and the… 
2010
2010
Angiogenesis and Tissue Engineering Research
Abstract : Centers on the development of new medical therapies and regenerative medicine approaches for the treatment of injured… 
Highly Cited
2008
Highly Cited
2008
An orally delivered small-molecule formulation with antiangiogenic and anticancer activity
Targeting angiogenesis, the formation of blood vessels, is an important modality for cancer therapy. TNP-470, a fumagillin analog… 
2008
2008
Hitting the mother lode of tumor angiogenesis
Despite promising early results, cancer therapy aimed at selective destruction of tumor blood vessels faces several hurdles… 
2008
2008
Lodamin (PEG-PLA-TNP-470), a novel formulation for oral administration of TNP-470 as a potent antiangiogenic and anti-cancer drug.
1118 Targeting angiogenesis, the formation of new blood vessels, is becoming an important strategy for cancer therapy. TNP-470… 
2008
2008
Angiogenesis: A less bitter pill
  • P. Goymer
  • Nature Reviews. Cancer
  • 2008
  • Corpus ID: 46098883
inhibitor TNP-470 is a potent suppressor of tumour growth and metastasis, but its use is limited because it requires lengthy… 
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