locked nucleic acid

Known as: LNA (nucleic acid) 
 
National Institutes of Health

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Highly Cited
2011
Highly Cited
2011
BACKGROUND The epidermal growth factor receptor (EGFR) mutation T790M is reported in approximately 50% of lung cancers with… (More)
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Highly Cited
2010
Highly Cited
2010
For the past 15-20 years, the intracellular delivery and silencing activity of oligodeoxynucleotides have been essentially… (More)
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Highly Cited
2008
Highly Cited
2008
MicroRNAs (miRNAs) are short, about 21 nucleotides in length, noncoding, regulatory RNA molecules representing a new layer in… (More)
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Highly Cited
2007
Highly Cited
2007
A series of antisense oligonucleotides (ASOs) containing either 2'-O-methoxyethylribose (MOE) or locked nucleic acid (LNA… (More)
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Highly Cited
2006
Highly Cited
2006
MicroRNAs represent a class of short (approximately 22 nt), noncoding regulatory RNAs involved in development, differentiation… (More)
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Highly Cited
2005
Highly Cited
2005
Therapeutic application of the recently discovered small interfering RNA (siRNA) gene silencing phenomenon will be dependent on… (More)
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Review
2004
Review
2004
Locked nucleic acid (LNA) is a nucleic acid analogue containing one or more LNA nucleotide monomers with a bicyclic furanose unit… (More)
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Highly Cited
2003
Highly Cited
2003
The specificity and reliability of locked nucleic acid (LNA) substitution at the 3' position of allele-specific PCR (AS-PCR… (More)
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Review
2001
Review
2001
Locked nucleic acid is an RNA derivative in which the ribose ring is constrained by a methylene linkage between the 2'-oxygen and… (More)
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Highly Cited
2000
Highly Cited
2000
Insufficient efficacy and/or specificity of antisense oligonucleotides limit their in vivo usefulness. We demonstrate here that a… (More)
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