linopirdine

Known as: 2H-Indol-2-one, 1,3-dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-, 3,3-bis(4-pyridylmethyl)-1-phenylindolin-2-one, 3,3-dipyridylmethyl-1-phenyl-2-indolinone 
 
National Institutes of Health

Papers overview

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Review
2009
Review
2009
KCNQ genes encode five Kv7 K(+) channel subunits (Kv7.1-Kv7.5). Four of these (Kv7.2-Kv7.5) are expressed in the nervous system… (More)
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Highly Cited
2006
Highly Cited
2006
The M-current (I(M)), comprised of Kv7 channels, is a voltage-activated K+ conductance that plays a key role in the control of… (More)
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Highly Cited
2004
Highly Cited
2004
Mutations in the gene encoding the K+ channel KCNQ2 cause neonatal epilepsy and myokymia, indicating that KCNQ2 regulates the… (More)
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Highly Cited
2004
Highly Cited
2004
KCNQ channel subunits are widely expressed in peripheral and central neurons, where they give rise to a muscarinic-sensitive… (More)
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Highly Cited
2003
Highly Cited
2003
Neuronal hyperexcitability is a feature of epilepsy and both inflammatory and neuropathic pain. M currents [IK(M)] play a key… (More)
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Highly Cited
2002
Highly Cited
2002
M-type K(+) currents (I(K(M))) play a key role in regulating neuronal excitability. In sympathetic neurons, M-channels are… (More)
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Highly Cited
2000
Highly Cited
2000
Retigabine [N-(2-amino-4-[fluorobenzylamino]-phenyl) carbamic acid; D-23129] is a novel anticonvulsant, unrelated to currently… (More)
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1998
1998
Linopirdine (3,3-bis(4-pyridinylmethyl)-1-phenylindolin-2-one, DUP996) is an extensively studied representative of a class of… (More)
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Highly Cited
1998
Highly Cited
1998
Linopirdine [DuP 996, 3, 3-bis(4-pyridinylmethyl)-1-phenylindolin-2-one], a putative cognition enhancing drug, increases… (More)
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Highly Cited
1995
Highly Cited
1995
1. Linopirdine (DuP 996) has been shown to enhance depolarization-induced release of several neurotransmitters in the CNS through… (More)
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