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leukoregulin

Secreted by activated natural killer lymphocytes as a 50-kDa glycoprotein lymphokine, Leukoregulin can up regulate the expression of hyaluronan and… Expand
National Institutes of Health

Related topics

Related topics

10 relations

Broader (2)

Antineoplastic Agents, HormonalLymphokines
Cytokine GeneCytokine Receptor BindingCytokine SignalingInhibition of Cell Proliferation
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1999
1999
Leukoregulin upregulation of prostaglandin endoperoxide H synthase-2 expression in human orbital fibroblasts.
Human orbital fibroblasts from patients with severe thyroid-associated ophthalmopathy are particularly susceptible to the actions… Expand
Highly Cited
1998
Highly Cited
1998
Leukoregulin induction of protein expression in human orbital fibroblasts: evidence for anatomical site-restricted cytokine-target cell interactions.
The molecular basis for the profound inflammatory response and the accumulation of hyaluronan in orbital connective tissues seen… Expand
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Highly Cited
1996
Highly Cited
1996
Leukoregulin Induction of Prostaglandin-Endoperoxide H Synthase-2 in Human Orbital Fibroblasts
Several proinflammatory cytokines can increase prostaglandin E2 (PGE2) synthesis in a variety of cell types, constituting an… Expand
Highly Cited
1995
Highly Cited
1995
Leukoregulin is a potent inducer of hyaluronan synthesis in cultured human orbital fibroblasts.
Leukoregulin, a 50-kDa glycoprotein lymphokine, can regulate the extracellular matrix in dermal fibroblasts. Here we investigate… Expand
1995
1995
Leukoregulin induces plasminogen activator inhibitor type 1 in human orbital fibroblasts.
Leukoregulin, a 50-kDa T lymphocyte-derived cytokine, influences the synthesis of collagenase, stromelysin-1, collagen, and… Expand
Highly Cited
1992
Highly Cited
1992
Leukoregulin and gamma-interferon inhibit human papillomavirus type 16 gene transcription in human papillomavirus-immortalized human cervical cells.
The human papillomavirus (HPV) transforming genes E6 and E7 are retained and expressed in the majority of cervical cancers… Expand
1989
1989
Preparative isoelectric focusing in ampholine electrofocusing columns versus immobiline polyacrylamide gel for the purification of biologically active leukoregulin.
Preparative vertical and rotating horizontal (Rotofor) ampholine column and immobiline flat bed polyacrylamide gel isoelectric… Expand
1986
1986
Leukoregulin-increased plasma membrane permeability and associated ionic fluxes.
The role of ion fluxes in the increased plasma membrane permeability of tumor cells exposed to the anticarcinogenic and tumor… Expand
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1986
1986
Analysis of cytostatic/cytotoxic lymphokines: relationship of natural killer cytotoxic factor to recombinant lymphotoxin, recombinant tumor necrosis factor, and leukoregulin.
Previous results that were obtained by using supernatants from the co-culture of human peripheral blood lymphocytes and the… Expand
Highly Cited
1985
Highly Cited
1985
Leukoregulin, a direct-acting anticancer immunological hormone that is distinct from lymphotoxin and interferon.
Human lymphokine preparations can directly lyse or suppress proliferation of human tumor cells or can enhance the susceptibility… Expand
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