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leukoregulin

Secreted by activated natural killer lymphocytes as a 50-kDa glycoprotein lymphokine, Leukoregulin can up regulate the expression of hyaluronan and… Expand
National Institutes of Health

Related topics

Related topics

10 relations

Broader (2)

Antineoplastic Agents, HormonalLymphokines
Cytokine GeneCytokine Receptor BindingCytokine SignalingInhibition of Cell Proliferation
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Papers overview

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1998
1998
Leukoregulin induction of protein expression in human orbital fibroblasts: evidence for anatomical site-restricted cytokine-target cell interactions.
The molecular basis for the profound inflammatory response and the accumulation of hyaluronan in orbital connective tissues seen… Expand
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1996
1996
Leukoregulin induction of prostaglandin-endoperoxide H synthase-2 in human orbital fibroblasts. An in vitro model for connective tissue inflammation.
Several proinflammatory cytokines can increase prostaglandin E2 (PGE2) synthesis in a variety of cell types, constituting an… Expand
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1995
1995
Leukoregulin is a potent inducer of hyaluronan synthesis in cultured human orbital fibroblasts.
Leukoregulin, a 50-kDa glycoprotein lymphokine, can regulate the extracellular matrix in dermal fibroblasts. Here we investigate… Expand
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1995
1995
Leukoregulin induces plasminogen activator inhibitor type 1 in human orbital fibroblasts.
Leukoregulin, a 50-kDa T lymphocyte-derived cytokine, influences the synthesis of collagenase, stromelysin-1, collagen, and… Expand
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1992
1992
Leukoregulin and gamma-interferon inhibit human papillomavirus type 16 gene transcription in human papillomavirus-immortalized human cervical cells.
The human papillomavirus (HPV) transforming genes E6 and E7 are retained and expressed in the majority of cervical cancers… Expand
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1992
1992
Decreased P-glycoprotein expression in multidrug-sensitive and -resistant human myeloma cells induced by the cytokine leukoregulin.
Modulation of the expression of P-glycoprotein, a plasma membrane protein associated with multidrug resistance, was examined in… Expand
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Review
1992
Review
1992
Cytokines as positive and negative regulators of tumor promotion and progression.
Cytokines can have both negative and positive effects on cells undergoing carcinogenesis. The promotion and progression phases of… Expand
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1989
1989
Preparative isoelectric focusing in ampholine electrofocusing columns versus immobiline polyacrylamide gel for the purification of biologically active leukoregulin.
Preparative vertical and rotating horizontal (Rotofor) ampholine column and immobiline flat bed polyacrylamide gel isoelectric… Expand
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1986
1986
Leukoregulin-increased plasma membrane permeability and associated ionic fluxes.
The role of ion fluxes in the increased plasma membrane permeability of tumor cells exposed to the anticarcinogenic and tumor… Expand
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1985
1985
Leukoregulin, a direct-acting anticancer immunological hormone that is distinct from lymphotoxin and interferon.
Human lymphokine preparations can directly lyse or suppress proliferation of human tumor cells or can enhance the susceptibility… Expand
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