leukemia inhibitory factor

Known as: Myeloid Differentiation Stimulating Factor, Inhibitory Factor, Leukemia, Differentiation-Stimulating Factor 
An INTERLEUKIN-6 related cytokine that exhibits pleiotrophic effects on many physiological systems that involve cell proliferation, differentiation… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1962-2018
05010019622018

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20 relations

Narrower (5)

AM424EmfilerminLIF geneLIF protein, human
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COMPLEMENT FACTOR DIn BloodProcess of secretionadipsin activity
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Broader (1)

cytokine

Related mentions per year

Related mentions per year

1936-2019
19401960198020002020
leukemia inhibitory factor
standards characteristics
cytokine
physiological aspects
chemical synthesis
COMPLEMENT FACTOR D

Papers overview

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Highly Cited
2010
Highly Cited
2010
Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs.
Human and mouse embryonic stem cells (ESCs) are derived from blastocyst-stage embryos but have very different biological… (More)
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Highly Cited
2009
Highly Cited
2009
Neuroprotective and axon growth-promoting effects following inflammatory stimulation on mature retinal ganglion cells in mice depend on ciliary neurotrophic factor and leukemia inhibitory factor.
After optic nerve injury retinal ganglion cells (RGCs) normally fail to regenerate axons in the optic nerve and undergo apoptosis… (More)
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Highly Cited
2005
Highly Cited
2005
LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism.
Murine ES cells can be maintained as a pluripotent, self-renewing population by LIF/STAT3-dependent signaling. The downstream… (More)
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Highly Cited
2000
Highly Cited
2000
Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy.
The roles that thymus cytokines might play in regulating thymic atrophy are not known. Reversing thymic atrophy is important for… (More)
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Highly Cited
1998
Highly Cited
1998
Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions
Leukemia inhibitory factor is essential for embryo implantation, and a shift from type 1 T-helper to type 2 T-helper response at… (More)
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Highly Cited
1998
Highly Cited
1998
Neural precursor differentiation into astrocytes requires signaling through the leukemia inhibitory factor receptor.
The differentiation of precursor cells into neurons or astrocytes in the developing brain has been thought to be regulated in… (More)
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Highly Cited
1996
Highly Cited
1996
Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. Assembly of sarcomeric units in series VIA gp130/leukemia inhibitory factor receptor-dependent pathways.
Cardiotrophin-1 (CT-1) was recently isolated by expression cloning based on its ability to induce an increase in cell size in… (More)
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Highly Cited
1996
Highly Cited
1996
Cytokine expression by human marrow-derived mesenchymal progenitor cells in vitro: effects of dexamethasone and IL-1 alpha.
We previously reported the purification, culture-expansion, and osteogenic differentiation potential of mesenchymal progenitor… (More)
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Highly Cited
1995
Highly Cited
1995
Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death.
The low-affinity receptor for leukemia inhibitory factor (LIFR) interacts with gp130 to induce an intracellular signal cascade… (More)
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Highly Cited
1994
Highly Cited
1994
Ciliary neurotrophic factor and leukemia inhibitory factor promote the generation, maturation and survival of oligodendrocytes in vitro.
We have found that CNTF and LIF are pleiotropic modulators of development in the O-2A lineage. Both molecules enhanced the… (More)
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