leprosy vaccine

Differentiated cells possess a remarkable genomic plasticity that can be manipulated to reverse or change developmental… (More)

Toll-like receptors (TLRs) are important regulators of the innate immune response to pathogens, including Mycobacterium leprae… (More)

Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacterial infections, and the mutations in the TLR2 have… (More)

A novel mechanism by which T cells contribute to host defense against microbial pathogens is release of the antimicrobial protein… (More)

Immune responses can be classified, according to the predominant cytokines involved, into type 1 (featuring interferon-gamma, IFN… (More)

IL-10 and IL-4 have been shown to exert an inhibitory effect on cell-mediated immune responses. Our previous studies of leprosy… (More)

Immunotherapy with Mycobacterium w vaccine was attempted in patients with borderline-borderline, borderline lepromatous (BL), or… (More)

Protection afforded by BCG (bacillus Calmette-Guérin) vaccines against tuberculosis and leprosy varies widely between different… (More)

The clinical forms of leprosy constitute a spectrum that correlates closely with the degree of cell-mediated immunity. Patients… (More)

Leprosy, a chronic infectious disease afflicting between 10 and 15 million people, is caused by the obligate intracellular… (More)