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lepirudin

Known as: Lepirudin recombinant, 1-Leu-2-Thr-63-desulfohirudin, Recombinant Hirudin 
A yeast cell-derived recombinant polypeptide related to the naturally occurring, leech-derived anticoagulant hirudin. Lepirudin directly binds to and… Expand
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
This chapter about the recognition, treatment, and prevention of heparin-induced thrombocytopenia (HIT) is part of the… Expand
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Review
2004
Review
2004
This chapter about the recognition, treatment, and prevention of heparin-induced thrombocytopenia (HIT) is part of the Seventh… Expand
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Highly Cited
2002
Highly Cited
2002
Complement plays an essential role in inflammation and tissue damage. However, it is largely unknown to what extent the system… Expand
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Highly Cited
2000
Highly Cited
2000
This meta-analysis focuses on 2 prospective studies in patients with heparin-induced thrombocytopenia (HIT) and thromboembolic… Expand
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Highly Cited
1999
Highly Cited
1999
BACKGROUND The immunological type of heparin-induced thrombocytopenia (HIT) is the most frequent drug-induced thrombocytopenia… Expand
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Highly Cited
1997
Highly Cited
1997
BACKGROUND Patients who undergo total hip replacement have a high risk of thromboembolic complications. Recombinant hirudin… Expand
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Highly Cited
1996
Highly Cited
1996
  • M. Simoons
  • The New England journal of medicine
  • 1996
  • Corpus ID: 2815702
BACKGROUND Thrombin has a pivotal role in the pathogenesis of acute coronary thrombosis. We compared the clinical efficacy of a… Expand
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Highly Cited
1995
Highly Cited
1995
BACKGROUND The likelihood of restenosis is a major limitation of coronary angioplasty. We studied whether hirudin, a highly… Expand
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Highly Cited
1994
Highly Cited
1994
BACKGROUND Although intravenous heparin is routinely used in the treatment of patients with acute coronary syndromes, this… Expand
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Highly Cited
1990
Highly Cited
1990
The crystallographic structure of a recombinant hirudin-thrombin complex has been solved at 2.3 angstrom (A) resolution. Hirudin… Expand
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