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lepirudin

Known as: Lepirudin recombinant, 1-Leu-2-Thr-63-desulfohirudin, Recombinant Hirudin 
A yeast cell-derived recombinant polypeptide related to the naturally occurring, leech-derived anticoagulant hirudin. Lepirudin directly binds to and… 
National Institutes of Health

Related topics

Related topics

11 relations
Angina, UnstableDrug AllergyMyocardial IschemiaThrombocytopenia

Broader (4)

AntithrombinsFibrinolytic AgentsHirudinsRecombinant Proteins

Narrower (2)

HBW 023Refludan

Papers overview

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Highly Cited
2004
Highly Cited
2004
Effect of complement inhibition and heparin coating on artificial surface-induced leukocyte and platelet activation.
Review
2003
Review
2003
Correlation of point-of-care ecarin clotting time versus activated clotting time with bivalirudin concentrations.
Highly Cited
1999
Highly Cited
1999
Immunologic response to recombinant hirudin in HIT type II patients during long‐term treatment
We prospectively investigated 27 patients with heparin‐induced thrombocytopenia (HIT) type II who were subsequently treated with… 
Highly Cited
1998
Highly Cited
1998
Emergent cardiopulmonary bypass in five patients with heparin-induced thrombocytopenia type II employing recombinant hirudin.
Highly Cited
1997
Highly Cited
1997
Anticoagulation with r-hirudin in regular haemodialysis with heparin-induced thrombocytopenia (HIT II). The first long-term application of r-hirudin in a haemodialysis patient.
A 69-year-old female patient with renal failure developed heparin-induced thrombocytopenia type II (HIT II) two months after… 
1994
1994
Production of recombinant hirudin by high cell density fed-batch cultivations of a Saccharomyces cerevisiae strain: physiological considerations during the bioprocess design.
1992
1992
Intrinsic fluorescence changes and rapid kinetics of the reaction of thrombin with hirudin.
Highly Cited
1989
Highly Cited
1989
Contribution of the N-terminal region of hirudin to its interaction with thrombin.
Hirudin is a 65-residue polypeptide that specifically inhibits thrombin by forming a tight, noncovalent complex with the enzyme… 
1989
1989
Point mutations modifying the thrombin inhibition kinetics and antithrombotic activity in vivo of recombinant hirudin.
The hirudin variant HV2 was modified by in vitro site-specific mutagenesis of HV2 cDNA to generate HV2(Asn-47----Lys), HV2(Asn-47… 
Highly Cited
1988
Highly Cited
1988
Expression and Secretion in S. Cerevisiae of Biologically Active Leech Hirudin
Hirudin synthesized by the medicinal leech Hirudo medicinalis is the most potent antithrombic factor found in nature. We have… 
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