lepirudin

Known as: Lepirudin recombinant, 1-Leu-2-Thr-63-desulfohirudin, Recombinant Hirudin 
A yeast cell-derived recombinant polypeptide related to the naturally occurring, leech-derived anticoagulant hirudin. Lepirudin directly binds to and… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
This chapter about the recognition, treatment, and prevention of heparin-induced thrombocytopenia (HIT) is part of the… (More)
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Highly Cited
2005
Highly Cited
2005
OBJECTIVES To assess efficacy and safety of lepirudin in patients with heparin-induced thrombocytopenia (HIT) in a prospective… (More)
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Review
2004
Review
2004
This chapter about the recognition, treatment, and prevention of heparin-induced thrombocytopenia (HIT) is part of the Seventh… (More)
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Highly Cited
2003
Highly Cited
2003
Trousseau described spontaneous, recurrent superficial migratory thrombophlebitis associated with occult cancers, and this was… (More)
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Highly Cited
2002
Highly Cited
2002
Complement plays an essential role in inflammation and tissue damage. However, it is largely unknown to what extent the system… (More)
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Highly Cited
2001
Highly Cited
2001
Heparin-induced thrombocytopenia (HIT) is a hypercoagulable syndrome strongly associated with thrombosis that is usually treated… (More)
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Highly Cited
2000
Highly Cited
1999
Highly Cited
1999
BACKGROUND The immunological type of heparin-induced thrombocytopenia (HIT) is the most frequent drug-induced thrombocytopenia… (More)
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Highly Cited
1990
Highly Cited
1990
The crystallographic structure of a recombinant hirudin-thrombin complex has been solved at 2.3 angstrom (A) resolution. Hirudin… (More)
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Highly Cited
1989
Highly Cited
1989
The effect of recombinant hirudin and the dosage of heparin on acute platelet-thrombus deposition during carotid angioplasty in… (More)
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