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There is a potential risk that 5-HT(1A) receptor blockade combined with blockade of the 5-HT transporter by an SSRI may cause a… Expand Lecozotan is a selective serotonergic 5-HT(1A) receptor antagonist previously shown to enhance task performance efficiency in… Expand AIMS
To determine the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of oral immediate release (IR) lecozotan in healthy… Expand This positron emission tomography (PET) study was conducted to assess binding of lecozotan, a new potent and silent 5… Expand L, a potent and silent 5HT1A antagonist, is being developed for the treatment of Alzheimer's disease (AD). This study, which used… Expand Lecozotan is a potent and silent 5‐HT1A antagonist being developed for the treatment of cognitive deficits associated with… Expand Lecozotan is a new potent and silent 5‐HT1A antagonist being developed for the treatment of cognitive deficits associated with… Expand Recent data has suggested that the 5-hydroxytryptamine (5-HT)1A receptor is involved in cognitive processing. A novel 5-HT1A… Expand A series of benzodioxanylpiperazine derivatives possessing a 4-aryl amide substituent was prepared and evaluated for 5-HT(1A… Expand