lanosterol 14 alpha-demethylase

Known as: Cytochrome P 450 CYP51, 14alpha-Demethylase, Obtusifoliol, Eburicol 14 alpha Demethylase 
An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols… (More)
National Institutes of Health

Papers overview

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2003
2003
Pneumocystis carinii (PC) causes severe pneumonia in immunocompromised patients. PC is intrinsically resistant to treatment with… (More)
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2001
2001
Binding of sterol response element binding protein 1a to sterol response element-1 (SRE-1) in the promoter region of lanosterol… (More)
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Highly Cited
2000
Highly Cited
2000
Six novel feruloyl esters of triterpene alcohols and sterols, viz., two trans-ferulates, cycloeucalenol and 24… (More)
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1996
1996
To determine the orthology of sterol 14-demethylase (P45014DM), the only known P450 enzyme distributed widely in eukaryotes with… (More)
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1995
1995
Agents that inhibit hepatic cholesterol biosynthesis reduce circulating cholesterol levels in experimental animals and humans… (More)
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1995
1995
Regulation of the activity of lanosterol 14 alpha-demethylase (cytochrome P-45014DM) by dietary cholesterol was studied in rats… (More)
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1994
1994
The discovery of selective lanosterol 14 alpha-demethylase inhibitors may lead to novel hypolipidemic drugs. RS-21607, (2S,4S… (More)
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1991
1991
Lanosterol 14 alpha-methyl demethylase was investigated in human tissues using a radio-HPLC assay to detect the 4,4-dimethyl-5… (More)
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1991
1991
A 32-carboxylic acid derivative of lanosterol (SKF 104976) was found to be a potent inhibitor of lanosterol 14 alpha-demethylase… (More)
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1986
1986
Employing reconstitution assays and measurement of cytochrome P-450 content, lanosterol 14 alpha-demethylase and cholesterol 7… (More)
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