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kynostatin 272

Known as: 4-Thiazolidinecarboxamide, N-(1,1-dimethylethyl)-3- [2-hydroxy-3-[[2-[[(5-isoquinolinyloxy)acetyl]amino]-3- (methylthio)-1-oxopropyl]amino]-1-oxo-4-phenylbutyl]-,[4R-[3[2S*, 3S*(R*)],4R*]], KNI-272, kynostatin-272 
A synthetic peptide-based antiviral agent. As a peptidomimetic substrate containing an unnatural amino acid, allophenylnorstatine, KNI-272… Expand
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
HIV-1 protease is a dimeric aspartic protease that plays an essential role in viral replication. To further understand the… Expand
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Highly Cited
2002
Highly Cited
2002
Amino acid substitutions in human immunodeficiency virus type 1 (HIV-1) Gag cleavage sites have been identified in HIV-1 isolated… Expand
Highly Cited
2000
Highly Cited
2000
KNI‐272 is a powerful HIV‐1 protease inhibitor with a reported inhibition constant in the picomolar range. In this paper, a… Expand
Highly Cited
1999
Highly Cited
1999
We designed, synthesized, and identified JE-2147, an allophenylnorstatine-containing dipeptide HIV protease inhibitor (PI), which… Expand
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Highly Cited
1999
Highly Cited
1999
The aspartyl dyad of free HIV‐1 protease has apparent pKas of ∼3 and ∼6, but recent NMR studies indicate that the aspartyl dyad… Expand
Highly Cited
1998
Highly Cited
1998
The activity of three human immunodeficiency virus (HIV) protease inhibitors was investigated in human primary monocytes… Expand
Highly Cited
1996
Highly Cited
1996
In order to improve the design of HIV-1 protease inhibitors, it is essential to understand how they interact with active site… Expand
Highly Cited
1995
Highly Cited
1995
Eleven different recombinant, drug-resistant HIV-1 protease (HIV PR) mutants--R8Q, V32I, M46I, V82A, V82F, V82I, I84V, V32I/I84V… Expand
Highly Cited
1995
Highly Cited
1995
BACKGROUND HIV-1 protease (HIV PR), an aspartic protease, cleaves Phe-Pro bonds in the Gag and Gag-Pol viral polyproteins… Expand
Highly Cited
1992
Highly Cited
1992
Selective and potent HIV protease inhibitors containing allophenylnorstatine [Apns; (2S, 3S)-3-amino-2-hydroxy-4-phenylbutyric… Expand