kinase inhibitor activity

Known as: kinase inhibitor 
Stops, prevents or reduces the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate… (More)

Topic mentions per year

Topic mentions per year

1974-2018
020040019742018

Papers overview

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Highly Cited
2011
Highly Cited
2011
BACKGROUND Idiopathic pulmonary fibrosis is a progressive lung disease with a high mortality rate. Because the signaling pathways… (More)
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Highly Cited
2007
Highly Cited
2007
Using MRI techniques, we show here that normalization of tumor vessels in recurrent glioblastoma patients by daily administration… (More)
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Highly Cited
2007
Highly Cited
2007
Oncogenic tyrosine kinases have proved to be promising targets for the development of highly effective anticancer drugs. However… (More)
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Highly Cited
2007
Highly Cited
2007
Molecularly targeted kinase inhibitor cancer therapies are currently administered sequentially rather than simultaneously. We… (More)
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Highly Cited
2006
Highly Cited
2006
PURPOSE To establish the safety, pharmacokinetics, and recommended dose of sunitinib, a novel oral multitargeting tyrosine kinase… (More)
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Highly Cited
2005
Highly Cited
2005
Inhibition of vascular endothelial growth factor-A (VEGF) signaling is a promising therapeutic approach that aims to stabilize… (More)
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Highly Cited
2005
Highly Cited
2005
Leukemic cells from 30% of patients with acute myeloid leukemia (AML) have an activating mutation in the FLT3 (fms-like tyrosine… (More)
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Highly Cited
2004
Highly Cited
2004
PURPOSE To evaluate the efficacy, safety, and pharmacokinetics of multiple doses of CCI-779, a novel mammalian target of… (More)
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Highly Cited
2002
Highly Cited
2002
PURPOSE To investigate the tolerability, pharmacokinetics, and antitumor activity of the oral, selective epidermal growth factor… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Increased activity of Rho-kinase causes hypercontraction of vascular smooth muscle and has been implicated as playing… (More)
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