isopenicillin N acyltransferase activity

Known as: isopenicillin-N N-acyltransferase activity, acyl-CoA:isopenicillin N N-acyltransferase activity, isopenicillin-N acyltransferase activity 
Catalysis of the reaction: phenylacetyl-CoA + isopenicillin N + H2O = CoA + penicillin G + L-2-aminohexanedioate. [EC:2.3.1.164, MetaCyc:2.3.1.164… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1975-2015
012319752015

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2007
2007
A carbocyclic analogue of the beta-lactam antibiotic isopenicillin N (IPN) has been synthesised and cocrystallised with… (More)
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2006
2006
A gene, phl, encoding a phenylacetyl-CoA ligase was cloned from a phage library of Penicillium chrysogenum AS-P-78. The presence… (More)
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2003
2003
Isopenicillin N synthase (IPNS) is a non-haem iron(II) oxidase which catalyses the biosynthesis of isopenicillin N from the… (More)
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Highly Cited
1997
Highly Cited
1997
The biosynthesis of penicillin and cephalosporin antibiotics in microorganisms requires the formation of the bicyclic nucleus of… (More)
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1993
1993
The isopenicillin-N acyltransferase of Penicillium chrysogenum catalyzes the conversion of the biosynthetic intermediate… (More)
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Highly Cited
1993
Highly Cited
1993
Transcription of the ipnA gene encoding isopenicillin N synthetase, an enzyme of secondary metabolism, is under the control of… (More)
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1986
1986
The content of alpha-aminoadipyl-cysteinyl-valine, the first intermediate of the penicillin biosynthetic pathway, decreased when… (More)
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1985
1985
The tripeptide delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine, an intermediate in the penicillin biosynthetic pathway, is… (More)
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1980
1980
Cell-free cyclization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine to isopenicillin N by lytic enzyme extracts of… (More)
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1975
1975
1. 3H was incorporated into solvent-soluble penicillin from isopenicillin N and 6-aminopenicillanic acid 3H-labelled in the 2beta… (More)
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