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isopenicillin N acyltransferase activity

Known as: isopenicillin-N N-acyltransferase activity, acyl-CoA:isopenicillin N N-acyltransferase activity, isopenicillin-N acyltransferase activity 
Catalysis of the reaction: phenylacetyl-CoA + isopenicillin N + H2O = CoA + penicillin G + L-2-aminohexanedioate. [EC:2.3.1.164, MetaCyc:2.3.1.164… 
National Institutes of Health

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acyltransferase activity

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Review
2004
Review
2004
Expression of genes and processing of enzymes for the biosynthesis of penicillins and cephalosporins
The genespcbAB,pcbC andpenDE encoding the enzymes (α-aminoadipyl-cysteinyl-valine synthetase, isopenicillin N synthase and… 
Review
2004
Review
2004
Recent advances in the structure and function of isopenicillin N synthase
Isopenicillin N synthase is a key enzyme in the biosynthesis of penicillin and cephalosporin antibiotics, catalyzing the… 
1998
1998
Analysis of the conversion of delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-alpha-aminobutyrate by active-site mutants of Aspergillus nidulans isopenicillin N synthase.
BACKGROUND Penicillins and cephalosporins constitute a major class of clinically useful antibiotics. A key step in their… 
1994
1994
Inhibition of penicillin biosynthetic enzymes by halogen derivatives of phenylacetic acid
SummaryThe effect of phenylacetic acid (PAA) and several analogs on the activity of isopenicillin N synthase (IPNS) and acyl-CoA… 
1992
1992
Oxygen utilisation by isopenicillin N synthase from Penicillium chrysogenum.
The enzyme isopenicillin N synthase (IPNS) converts delta-(L-alpha- aminoadipyl)-L-cysteinyl-D-valine (ACV) to isopenicillin N… 
Review
1991
Review
1991
Genes directly involved in the biosynthesis of beta-lactam antibiotics.
Several genes encoding enzymatic activities involved in penicillin and cephalosporin biosynthesis have been identified. The first… 
1982
1982
High performance liquid chromatography (HPLC) of natural products V. The use of HPLC in the cell-free biosynthetic conversion of alpha-aminoadipyl-cysteinyl-valine (LLD) into isopenicillin N.
Isopenicillin N (I) and penicillin N (II) were separated effectively by reversed phase HPLC as derivatives of chiral 2, 3, 4, 6… 
1982
1982
Antibiotic activity of pure penicillin N and isopenicillin N.
Highly Cited
1979
Highly Cited
1979
Incorporation of 3H from delta-(L-alpha-amino (4,5-3H)adipyl)-L-cysteinyl-D-(4,4-3H)valine into isopenicillin N.
1. delta-(L-alpha-Amino[4,5-3H]adipyl)-L-cysteinyl-D-[4,4-3H]valine has been synthesized from its constituent amino acids, the L… 
1975
1975
Synthesis of tritium-labelled isopenicillin N, penicillin N and 6-aminopenicillanic acid.
1. Phenoxymethylpenicillin sulphoxide 4-methoxybenzyl ester was labelled with 3H in its 2-beta-methyl group. Its specific… 
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