isomethadone

Known as: 6-(dimethylamino)-5-methyl-4,4-diphenyl-3-hexanone

National Institutes of Health

Papers overview

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1982

1982

Synthesis, X-ray crystallographic determination, and opioid activity of erythro-5-methylmethadone enantiomers. Evidence which suggests that mu and delta opioid receptors possess different…

P. Portoghese, J. Poupaert, +5 authors W. Duax
Journal of medicinal chemistry
1982

Corpus ID: 43281190

Enantiomers of erythro-5-methylmethadone (3) were synthesized from optical antipodes of erythro-3-(dimethyl-amino)-2-butanol. X… Expand

1976

1976

Stereochemical studies on medicinal agents. 21. Investigation of the role of conformational factors in the action of diphenylpropylamines. Synthesis and analgetic potency of 5-methylmethadone…

J. Henkel, E. Berg, P. Portoghese
Journal of medicinal chemistry
1976

Corpus ID: 35673855

The synthesis of racemic threo- and erythro-5-methylmethadone (3a and 3b, respectively) was carried out and the solution… Expand

1974

1974

Stereochemical studies on medicinal agents. 16. Conformational studies of methadone and isomethadone utilizing circular dichroism and proton magnetic resonance.

J. Henkel, K. H. Bell, P. Portoghese
Journal of medicinal chemistry
1974

Corpus ID: 39121268

1973

1973

[Stereoselectivity of the reduction of isomethadone (author's transl)].

R. Haller, R. Rümmler
Archiv der Pharmazie
1973

Corpus ID: 31123732

1971

1971

Identification and quantitative determination of some metabolites of methadone, isomethadone and normethadone

A. Beckett, M. Mitchard, A. A. Shihab
The Journal of pharmacy and pharmacology
1971

Corpus ID: 40242015

Isomethadone and normethadone are metabolized by microsomal preparations of guinea‐pig liver to yield 2‐ethyl‐1,4‐dimethyl‐3,3… Expand

1967

1967

Analgesically active basic anilides: stereospecificity and structure of the basic group

A. Casy, M. Hassan
The Journal of pharmacy and pharmacology
1967

Corpus ID: 38501282

The synthesis of (RS)‐, (R)‐ and (S)‐N‐(2‐dimethylaminopropyl)propionanilide and the benzylmethylamino‐ analogues of methadone… Expand