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isomethadone
Known as:
6-(dimethylamino)-5-methyl-4,4-diphenyl-3-hexanone
National Institutes of Health
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Methadone
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1982
1982
Synthesis, X-ray crystallographic determination, and opioid activity of erythro-5-methylmethadone enantiomers. Evidence which suggests that mu and delta opioid receptors possess different…
P. Portoghese
,
J. Poupaert
,
+5 authors
W. Duax
Journal of Medicinal Chemistry
1982
Corpus ID: 43281190
Enantiomers of erythro-5-methylmethadone (3) were synthesized from optical antipodes of erythro-3-(dimethyl-amino)-2-butanol. X…
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1976
1976
Stereochemical studies on medicinal agents. 21. Investigation of the role of conformational factors in the action of diphenylpropylamines. Synthesis and analgetic potency of 5-methylmethadone…
J. Henkel
,
E. Berg
,
P. Portoghese
Journal of Medicinal Chemistry
1976
Corpus ID: 35673855
The synthesis of racemic threo- and erythro-5-methylmethadone (3a and 3b, respectively) was carried out and the solution…
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1974
1974
Stereochemical studies on medicinal agents. 16. Conformational studies of methadone and isomethadone utilizing circular dichroism and proton magnetic resonance.
J. Henkel
,
K. H. Bell
,
P. Portoghese
Journal of Medicinal Chemistry
1974
Corpus ID: 39121268
1973
1973
[Stereoselectivity of the reduction of isomethadone (author's transl)].
R. Haller
,
R. Rümmler
Archiv der Pharmazie
1973
Corpus ID: 31123732
1971
1971
Identification and quantitative determination of some metabolites of methadone, isomethadone and normethadone
A. Beckett
,
M. Mitchard
,
A. A. Shihab
The Journal of pharmacy and pharmacology
1971
Corpus ID: 40242015
Isomethadone and normethadone are metabolized by microsomal preparations of guinea‐pig liver to yield 2‐ethyl‐1,4‐dimethyl‐3,3…
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1967
1967
Analgesically active basic anilides: stereospecificity and structure of the basic group
A. F. CASY
,
M. Hassan
The Journal of pharmacy and pharmacology
1967
Corpus ID: 38501282
The synthesis of (RS)‐, (R)‐ and (S)‐N‐(2‐dimethylaminopropyl)propionanilide and the benzylmethylamino‐ analogues of methadone…
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