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isomethadone

Known as: 6-(dimethylamino)-5-methyl-4,4-diphenyl-3-hexanone 
 
National Institutes of Health

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Methadone

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1982
1982
Synthesis, X-ray crystallographic determination, and opioid activity of erythro-5-methylmethadone enantiomers. Evidence which suggests that mu and delta opioid receptors possess different…
Enantiomers of erythro-5-methylmethadone (3) were synthesized from optical antipodes of erythro-3-(dimethyl-amino)-2-butanol. X… Expand
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1976
1976
Stereochemical studies on medicinal agents. 21. Investigation of the role of conformational factors in the action of diphenylpropylamines. Synthesis and analgetic potency of 5-methylmethadone…
The synthesis of racemic threo- and erythro-5-methylmethadone (3a and 3b, respectively) was carried out and the solution… Expand
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1974
1974
Stereochemical studies on medicinal agents. 16. Conformational studies of methadone and isomethadone utilizing circular dichroism and proton magnetic resonance.
 
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1973
1973
[Stereoselectivity of the reduction of isomethadone (author's transl)].
 
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1971
1971
Identification and quantitative determination of some metabolites of methadone, isomethadone and normethadone
Isomethadone and normethadone are metabolized by microsomal preparations of guinea‐pig liver to yield 2‐ethyl‐1,4‐dimethyl‐3,3… Expand
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1967
1967
Analgesically active basic anilides: stereospecificity and structure of the basic group
The synthesis of (RS)‐, (R)‐ and (S)‐N‐(2‐dimethylaminopropyl)propionanilide and the benzylmethylamino‐ analogues of methadone… Expand
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