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isoleucine catabolic process

Known as: isoleucine breakdown, isoleucine catabolism, isoleucine degradation 
The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid. [GOC:ai]
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
The metabolome profiling and pathway analysis in metabolic healthy and abnormal obesity
Objectives:Mechanisms of the development of abnormal metabolic phenotypes among obese population are not yet clear. In this study… Expand
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Highly Cited
2012
Highly Cited
2012
Gene expression profiling of nephrotoxicity from copper nanoparticles in rats after repeated oral administration.
The goal of this study was to investigate the mechanisms of nanocopper-induced nephrotoxicity by analyzing renal gene expression… Expand
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Highly Cited
2010
Highly Cited
2010
Microarray analysis of the gene expression profile in the midgut of silkworm infected with cytoplasmic polyhedrosis virus
In order to obtain an overall view on silkworm response to Bombyx mori cytoplasmic polyhedrosis virus (BmCPV) infection, a… Expand
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2010
2010
A common mutation, R208X, identified in Vietnamese patients with mitochondrial acetoacetyl-CoA thiolase (T2) deficiency.
Mitochondrial acetoacetyl-CoA thiolase (T2) deficiency is an inborn error of metabolism affecting isoleucine catabolism and… Expand
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Highly Cited
2006
Highly Cited
2006
Nine 3-ketoacyl-CoA thiolases (KATs) and acetoacetyl-CoA thiolases (ACATs) encoded by five genes in Arabidopsis thaliana are targeted either to peroxisomes or cytosol but not to mitochondria
The sub-cellular location of enzymes of fatty acid β-oxidation in plants is controversial. In the current debate the role and… Expand
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Highly Cited
2003
Highly Cited
2003
2-Methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency is caused by mutations in the HADH2 gene.
2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency is a novel inborn error of isoleucine degradation. In this article… Expand
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2000
2000
Isolated 2-methylbutyrylglycinuria caused by short/branched-chain acyl-CoA dehydrogenase deficiency: identification of a new enzyme defect, resolution of its molecular basis, and evidence for…
Acyl-CoA dehydrogenase (ACAD) defects in isoleucine and valine catabolism have been proposed in clinically diverse patients with… Expand
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1986
1986
Leucine and isoleucine activate skeletal muscle branched-chain alpha-keto acid dehydrogenase in vivo.
The response of rat skeletal muscle branched-chain alpha-keto acid dehydrogenase to administration of branched-chain amino acids… Expand
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1979
1979
Acetoacetyl CoA thiolase deficiency: a cause of severe ketoacidosis in infancy simulating salicylism.
A female child presented at one year of age with a febrile illness and loose stools, then developed severe ketoacidosis with… Expand
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Highly Cited
1971
Highly Cited
1971
A "new" disorder of isoleucine catabolism.
A disorder of isoleucine catabolism was found in a child with intermittent metabolic acidosis. The block occurs at the stage of… Expand
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