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isodialuric acid

Known as: 5,6-dihydroxy-2,4(1H,3H)pyrimidinedione, 5,6-dihydroxyuracil 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Uracil
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Oxidation reactions of cytosine DNA components by hydroxyl radical and one-electron oxidants in aerated aqueous solutions.
Indirect evidence strongly suggests that oxidation reactions of cytosine and its minor derivative 5-methylcytosine play a major… Expand
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Review
2007
Review
2007
Uracil in DNA--general mutagen, but normal intermediate in acquired immunity.
Deamination of cytosine in DNA results in mutagenic U:G mispairs, whereas incorporation of dUMP leads to U:A pairs that may be… Expand
2007
2007
Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress
Oxidative stress in the brain may cause neuro-degeneration, possibly due to DNA damage. Oxidative base lesions in DNA are mainly… Expand
2004
2004
Oxidation of 5-hydroxy-2'-deoxyuridine into isodialuric acid, dialuric acid, and hydantoin products.
Oxidation products of cytosine, including 5-hydroxycytosine and 5-hydroxyuracil, are highly susceptible to subsequent oxidation… Expand
Highly Cited
2000
Highly Cited
2000
Novel substrates of Escherichia coli nth protein and its kinetics for excision of modified bases from DNA damaged by free radicals.
Escherichia coli Nth protein (endonuclease III) is a DNA glycosylase with a broad substrate specificity for pyrimidine… Expand
Highly Cited
1997
Highly Cited
1997
Oxidative DNA base damage and its repair in kidneys and livers of nickel(II)-treated male F344 rats.
DNA base damage was assayed using gas chromatography/ mass spectrometry with selected ion monitoring (GC/MS-SIM) in renal and… Expand
Highly Cited
1996
Highly Cited
1996
Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage.
Uracil DNA N-glycosylase is a repair enzyme that releases uracil from DNA. A major function of this enzyme is presumably to… Expand
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1995
1995
A novel activity of E. coli uracil DNA N‐glycosylase excision of isodialuric acid (5,6‐dihydroxyuracil), a major product of oxidative DNA damage, from DNA
We describe a novel activity of E. coli uracil DNA N‐glycosylase (UNG) that excises isodialuric acid from DNA. Isodialuric acid… Expand
Highly Cited
1994
Highly Cited
1994
DNA base modifications in renal chromatin of wistar rats treated with a renal carcinogen, ferric nitrilotriacetate
Ferric nitrilotriacetate (Fe‐NTA) causes renal proximal tubular necrosis, a consequence of iron ion‐mediated free‐radical… Expand
Highly Cited
1986
Highly Cited
1986
Formation of cytosine glycol and 5,6-dihydroxycytosine in deoxyribonucleic acid on treatment with osmium tetroxide.
OsO4 selectively forms thymine glycol lesions in DNA. In the past, OsO4-treated DNA has been used as a substrate in studies of… Expand
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