FAQ

isodialuric acid

Known as: 5,6-dihydroxy-2,4(1H,3H)pyrimidinedione, 5,6-dihydroxyuracil 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1986-2016
01219862016

Related topics

Related topics

2 relations

Broader (1)

Uracil
analogs & derivatives

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
isodialuric acid
Uracil
analogs & derivatives

Papers overview

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2010
2010
Oxidation reactions of cytosine DNA components by hydroxyl radical and one-electron oxidants in aerated aqueous solutions.
Indirect evidence strongly suggests that oxidation reactions of cytosine and its minor derivative 5-methylcytosine play a major… (More)
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2006
2006
Formation of isodialuric acid lesion within DNA oligomers via one-electron oxidation of 5-hydroxyuracil: characterization, stability and excision repair
5-Hydroxyuracil is a major oxidized nucleobase that can be generated by the action of (*)OH radical and one-electron oxidants… (More)
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2004
2004
Oxidation of 5-hydroxy-2'-deoxyuridine into isodialuric acid, dialuric acid, and hydantoin products.
Oxidation products of cytosine, including 5-hydroxycytosine and 5-hydroxyuracil, are highly susceptible to subsequent oxidation… (More)
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2000
2000
Novel substrates of Escherichia coli nth protein and its kinetics for excision of modified bases from DNA damaged by free radicals.
Escherichia coli Nth protein (endonuclease III) is a DNA glycosylase with a broad substrate specificity for pyrimidine… (More)
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1997
1997
Oxidative DNA base damage and its repair in kidneys and livers of nickel(II)-treated male F344 rats.
DNA base damage was assayed using gas chromatography/ mass spectrometry with selected ion monitoring (GC/MS-SIM) in renal and… (More)
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1996
1996
Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage.
Uracil DNA N-glycosylase is a repair enzyme that releases uracil from DNA. A major function of this enzyme is presumably to… (More)
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1995
1995
A novel activity of E. coli uracil DNA N-glycosylase excision of isodialuric acid (5,6-dihydroxyuracil), a major product of oxidative DNA damage, from DNA.
We describe a novel activity of E. coli uracil DNA N-glycosylase (UNG) that excises isodialuric acid from DNA. Isodialuric acid… (More)
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1994
1994
DNA base modifications in renal chromatin of Wistar rats treated with a renal carcinogen, ferric nitrilotriacetate.
Ferric nitrilotriacetate (Fe-NTA) causes renal proximal tubular necrosis, a consequence of iron ion-mediated free-radical… (More)
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1993
1993
DNA base damage generated in vivo in hepatic chromatin of mice upon whole body gamma-irradiation.
DNA base lesions in hepatic chromatin formed upon whole-body irradiation of mice were studied. After gamma-irradiating (20-470 Gy… (More)
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1986
1986
Formation of cytosine glycol and 5,6-dihydroxycytosine in deoxyribonucleic acid on treatment with osmium tetroxide.
OsO4 selectively forms thymine glycol lesions in DNA. In the past, OsO4-treated DNA has been used as a substrate in studies of… (More)
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