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iron bleomycin

 
National Institutes of Health

Papers overview

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2000
2000
Bleomycin (Blm) is an antitumor agent that requires iron and oxygen for strand cleavage of DNA. In this study, ferric bleomycin… Expand
1995
1995
Kinetic parameters for the oxidation of D-ribose, 2-deoxy-~-nbose, adenosine 5’-monophosphate (AMP), adenosine 5‘-diphosphate… Expand
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1994
1994
DNA strand scission initiated by bleomycin is a multistep process. Three C-C or C-O bonds are broken, releasing base propenal, a… Expand
1994
1994
Studies with Euglena gracilis and HL-60 cells have assessed the need for intracellular iron in the mechanisms of inhibition of… Expand
1994
1994
0.8 min) concurrently with base propenal. Since strand scis- sion precedes phosphomonoester formation, strand scission cannot… Expand
1991
1991
The reaction of ferrous bleomycin with dioxygen is reexamined to clarify whether radical species derived from molecular oxygen… Expand
Highly Cited
1990
Highly Cited
1990
A comparison of the intracellular DNA strand scission activities of the antitumor drug bleomycin, three of its metal complexes… Expand
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1984
1984
In the presence of NADPH and O2, NADPH-cytochrome P-450 reductase was found to activate Fe(III)-bleomycin A2 for DNA strand… Expand
Highly Cited
1983
Highly Cited
1983
Using Mössbauer spectroscopy, we have examined iron-bleomycin in various oxidation states and in complexes with dioxygen or… Expand
1979
1979
Abstract Iron(III)bleomycin undergoes a redox reaction with thiols. Evidence from epr and UV-visible absorbance spectra indicate… Expand