intrinsic apoptotic signaling pathway

Known as: intrinsic apoptotic pathway, intrinsic apoptotic signalling pathway, mitochondrial-mediated apoptotic pathway 
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with… (More)
National Institutes of Health

Papers overview

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Review
2015
Review
2015
Apoptosis is a metazoan process of controlled cell elimination that plays critical roles in embryonic development and adult… (More)
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2014
2014
Essential oils of Cymbopogon citratus were already reported to have wide ranging medical and industrial applications. However… (More)
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Highly Cited
2013
Highly Cited
2013
The identification of recurrent somatic mutations in genes encoding epigenetic enzymes has provided a strong rationale for the… (More)
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2011
2011
Growth Arrest Specific 1 (GAS1) is a protein expressed when cells are arrested and during development. When ectopically expressed… (More)
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Review
2010
Review
2010
Apoptosis is a critical process for the maintenance of tissue homeostasis and prevention of tumorigenesis. The members of the Bcl… (More)
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Highly Cited
2009
Highly Cited
2009
OBJECTIVE Proinflammatory cytokines are cytotoxic to beta-cells and have been implicated in the pathogenesis of type 1 diabetes… (More)
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Review
2009
Review
2009
Programmed cell death, or apoptosis, is important for the development and homeostasis of tissues. Too little cell death can… (More)
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Highly Cited
2008
Highly Cited
2008
Raf/MEK/Erk signaling is activated in the majority of acute myeloid leukemias (AMLs), providing rationale for targeting this… (More)
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Review
2006
Review
2006
Few things can be considered to be more important to a cell than its threshold for apoptotic cell death, which can be modulated… (More)
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Highly Cited
2002
Highly Cited
2002
Accumulation of misfolded proteins and alterations in Ca2+ homeostasis in the endoplasmic reticulum (ER) causes ER stress and… (More)
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