FAQ

intestinal folate absorption

Uptake of folic into the blood by absorption from the small intestine. [GOC:BHF, GOC:dos, GOC:hal, PMID:19762432]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1977-2017
024619772017

Papers overview

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2014
2014
Modulation of intestinal folate absorption by erythropoietin in vitro.
Besides the direct stimulation of erythropoiesis, erythropoietin (EPO) therapy in renal anemia may also play a regulatory role in… (More)
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2012
2012
Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1).
The proton-coupled folate transporter (PCFT) mediates intestinal folate absorption, and loss-of-function mutations in this gene… (More)
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2010
2010
The obligatory intestinal folate transporter PCFT (SLC46A1) is regulated by nuclear respiratory factor 1.
Folates are essential vitamins that play a key role as one-carbon donors in a spectrum of biosynthetic pathways including RNA and… (More)
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2010
2010
Membrane topological analysis of the proton-coupled folate transporter (PCFT-SLC46A1) by the substituted cysteine accessibility method.
The proton-coupled folate transporter (PCFT) mediates intestinal folate absorption. Loss-of-function mutations in this gene are… (More)
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2009
2009
The functional roles of the His247 and His281 residues in folate and proton translocation mediated by the human proton-coupled folate transporter SLC46A1.
This report addresses the functional role of His residues in the proton-coupled folate transporter (PCFT; SLC46A1), which… (More)
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2009
2009
A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosis.
Recently, this laboratory identified a proton-coupled folate transporter (PCFT), with optimal activity at low pH. PCFT is… (More)
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2009
2009
Hypermethylation of the human proton-coupled folate transporter (SLC46A1) minimal transcriptional regulatory region in an antifolate-resistant HeLa cell line.
This laboratory recently identified a novel proton-coupled folate transporter (PCFT) that mediates intestinal folate absorption… (More)
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2007
2007
Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction.
This laboratory recently identified a human gene that encodes a novel folate transporter [Homo sapiens proton-coupled folate… (More)
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2007
2007
The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption.
Hereditary folate malabsorption (HFM) is a rare autosomal recessive disorder caused by impaired intestinal folate absorption and… (More)
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2003
2003
Folate uptake in the human intestine: promoter activity and effect of folate deficiency.
The intestinal folate absorption process occurs via a specialized mechanism that involves the reduced folate carrier (RFC). In… (More)
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