interleukin-6 receptor activity

Known as: IL-6 receptor activity, IL-6R, gp130 
Combining with interleukin-6 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
OBJECTIVE To investigate the efficacy of a murine anti-interleukin-6 receptor (anti-IL-6R) antibody in directly blocking tumor… (More)
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Review
2006
Review
2006
Interleukin-6 (IL-6) is a cytokine, which plays an important role in many chronic inflammatory diseases. IL-6 belongs to a family… (More)
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Review
2005
Review
2005
Inflammatory mechanisms play a key role in the pathogenesis of type 1 diabetes. Individuals who progress to type 2 diabetes… (More)
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Highly Cited
2004
Highly Cited
2004
Alterations of TGF-beta signaling have been described in colorectal cancer, although the molecular consequences are largely… (More)
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Highly Cited
2003
Highly Cited
2003
Interleukin-6 (IL-6) activates cells by binding to the membrane-bound IL-6 receptor (IL-6R) and subsequent formation of a… (More)
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Highly Cited
2003
Highly Cited
2003
OBJECTIVE To investigate whether interleukin-6 (IL-6) is a regulator of vascular endothelial growth factor (VEGF) in rheumatoid… (More)
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Highly Cited
1998
Highly Cited
1998
Seroepidemiology and polymerase chain reaction studies have strongly suggested that human herpesvirus type 8 (HHV-8) is… (More)
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Highly Cited
1998
Highly Cited
1998
There is some evidence that the pathophysiology of schizophrenia is related to activation of the inflammatory response system… (More)
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Highly Cited
1995
Highly Cited
1995
We reported that interleukin (IL) 6 alone cannot induce osteoclast formation in cocultures of mouse bone marrow and osteoblastic… (More)
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Highly Cited
1994
Highly Cited
1994
The effects of dexamethasone on the growth of four human multiple myeloma cell lines were studied. In addition, the effects on… (More)
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