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Interleukin-21 is a common γ-chain cytokine that controls the immune responses of B cells, T cells, and natural killer cells… Expand Guiding immune cells to the center Germinal centers (GCs) are the site of antibody affinity maturation. The GC response… Expand Bone marrow monocytes are primarily committed to osteoclast formation. It is, however, unknown whether potential primary… Expand Systemic lupus erythematosus (SLE) is an autoimmune disease in which abnormal immune responses are mediated by tissue‐binding… Expand ABSTRACT Interleukin-21 (IL-21) can be produced by CD8 T cells from HIV-1-infected individuals and those with autoimmune disease… Expand Function exhaustion of specific cytotoxic CD8+ T cell in chronic virus infection partly results from the low levels of CD4 help… Expand Interleukin (IL)‐21‐producing CD4+T cells are central to humoral immunity. Deciphering the signals that induce IL‐21 production… Expand Female mice lacking DEF6 and SWAP70 develop a lupus-like syndrome through dysregulation of IRF4 in activated B cells and plasma… Expand Previous studies have shown that IL‐6 potently induces IL‐21 production in CD4+ T cells, whereas TGF‐β inhibits IL‐6‐induced IL… Expand The T helper 17 (Th17) cell lineage is important in inflammatory and autoimmune responses, via its ability to produce interleukin… Expand