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Type I interferon (IFN) is a common therapy for autoimmune and inflammatory disorders, yet the mechanisms of action are largely… Expand OBJECTIVE
NALP3, ASC, and TUCAN are components of the NALP3 inflammasome, which triggers caspase 1-mediated interleukin-1beta (IL… Expand The production of interleukin-1 (IL-1) by cultured neonatal rat microglia was studied using the D10 cell assay. The results show… Expand We have demonstrated that IL-4 markedly inhibits IL-1 production by highly purified normal human monocytes. When added to… Expand Systemic reactions resembling inflammation occur in patients undergoing cardiopulmonary bypass. We now report that interleukin-1… Expand Potent interleukin-1 (IL-1) activity was detected in culture supernatants from synovium, obtained by arthroscopy, from rheumatoid… Expand IL-1 possesses several biologic properties, some of which are associated with chronic inflammatory diseases. We have recently… Expand Human peripheral blood monocytes and activated, but not resting, lymphocytes possess specific intracellular receptors for the… Expand Recent evidence indicates that stress can suppress immune responses and thus increase the severity of viral and neoplastic… Expand We have investigated the role of arachidonic acid metabolites in the regulation of interleukin-1 production by murine peritoneal… Expand