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insulin-glutathione transhydrogenase activity

Known as: protein-dithiol:NAD(P)+ oxidoreductase activity, protein disulfide reductase activity, protein disulphide reductase activity 
Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+. [EC:1.8.1.8, MetaCyc:1.6.4.4-RXN]
National Institutes of Health

Papers overview

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Review
2015
Review
2015
SIGNIFICANCE All cells must maintain a balance between oxidants and reductants, while allowing for fluctuations in redox states… Expand
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Highly Cited
2013
Highly Cited
2013
Background: The Cys-62/Cys-69 dithiol of Trx1 is predicted to have a profound effect on cell signaling. Results: The Cys-62/Cys… Expand
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Highly Cited
2009
Highly Cited
2009
MINT‐7017101, MINT‐7017183: NTRC (uniprotkb:Q70G58) and 2cys Prx (uniprotkb:Q6ER94) bind (MI:0407) by enzymatic studies (MI:0415) 
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Highly Cited
2006
Highly Cited
2006
Thioredoxin is ubiquitous and regulates various target proteins through disulfide bond reduction. We report the structure of… Expand
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Highly Cited
2001
Highly Cited
2001
Helicobacter pylori, an oxygen-sensitive microaerophile, contains an alkyl hydroperoxide reductase homologue (AhpC, HP1563) that… Expand
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Highly Cited
1998
Highly Cited
1998
We have identified an RNA polymerase sigma factor, σR, that is part of a system that senses and responds to thiol oxidation in… Expand
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Highly Cited
1998
Highly Cited
1998
We have identified an RNA polymerase sigma factor, sigmaR, that is part of a system that senses and responds to thiol oxidation… Expand
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Highly Cited
1996
Highly Cited
1996
In activated human neutrophils a burst of nitric oxide (NO) converts intracellular GSH to S-nitrosoglutathione (GSNO) which is… Expand
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Highly Cited
1995
Highly Cited
1995
Human thioredoxin reductase is a dimeric enzyme that catalyzes reduction of the disulfide in oxidized thioredoxin by a mechanism… Expand
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Highly Cited
1972
Highly Cited
1972
The biochemical and morphological changes of the yeastlike (Y) form to the mycelial (M) form of Paracoccidioides brasiliensis… Expand
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