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inositol-1,3,4,5-tetrakisphosphate

Known as: myo-inositol-1,3,4,5-tetrakisphosphate, Ins(1,3,4,5)P4, inositol-1,3,4,5-tetraphosphate 
National Institutes of Health

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2 relations

Broader (2)

Inositol Phosphatesinositol triphosphate

Papers overview

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Highly Cited
2003
Highly Cited
2003
Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change.
Protein kinase B (PKB/Akt) is a key regulator of cell growth, proliferation and metabolism. It possesses an N-terminal pleckstrin… 
Highly Cited
1996
Highly Cited
1996
Mutation of the Pleckstrin Homology Domain of Bruton's Tyrosine Kinase in Immunodeficiency Impaired Inositol 1,3,4,5-Tetrakisphosphate Binding Capacity*
Bruton's tyrosine kinase (Btk), a cytoplasmic protein-tyrosine kinase, plays a pivotal role in B cell activation and development… 
Highly Cited
1992
Highly Cited
1992
Inositol 1,3,4,5-tetrakisphosphate activates an endothelial Ca2+-permeable channel
RECEPTOR-MEDIATED increases in the cytosolic free calcium ion concentration in most mammalian cells result from mobilization of… 
Review
1989
Review
1989
Inositol phosphates and cell signalling
Inositol 1,4,5-trisphosphate is a second messenger which regulates intracellular calcium both by mobilizing calcium from internal… 
Highly Cited
1987
Highly Cited
1987
Characterization of inositol trisphosphate receptor binding in brain. Regulation by pH and calcium.
Highly Cited
1987
Highly Cited
1987
Synergism of inositol trisphosphate and tetrakisphosphate in activating Ca2+-dependent K+ channels
Inositol 1,4,5-trisphosphate (Ins P3) is a second messenger releasing intracellular Ca2+ into the cytosol–5. It has recently been… 
Highly Cited
1986
Highly Cited
1986
The inositol tris/tetrakisphosphate pathway—demonstration of Ins(l,4,5)P3 3-kinase activity in animal tissues
Recent advances in our understanding of the role of inositides in cell signalling have led to the central hypothesis that a… 
Highly Cited
1986
Highly Cited
1986
Formation and metabolism of inositol 1,3,4,5-tetrakisphosphate in liver.
The inositol lipid pools of isolated rat hepatocytes were labeled with [3H]myo-inositol, stimulated maximally with vasopressin… 
Highly Cited
1986
Highly Cited
1986
Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland.
When [3H]inositol-prelabelled rat parotid-gland slices were stimulated with carbachol, noradrenaline or Substance P, the major… 
Highly Cited
1985
Highly Cited
1985
Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices.
Carbachol stimulation of muscarinic receptors in rat cortical slices prelabelled with myo-[2-3H]inositol caused the rapid… 
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