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inositol 1,4,5-trisphosphate phosphatase activity

Known as: D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase activity, Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase activity, inositol polyphosphate-5-phosphatase activity 
Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5… 
National Institutes of Health

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inositol trisphosphate phosphatase activityinositol-1,4,5-trisphosphate 5-phosphatase activity

Papers overview

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Review
2017
Review
2017
The 5-phosphatase OCRL in Lowe syndrome and Dent disease 2
Lowe syndrome is an X-linked disease that is characterized by congenital cataracts, central hypotonia, intellectual disability… 
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2014
2014
A novel OCRL1 mutation in a patient with the mild phenotype of Lowe syndrome.
Oculocerebrorenal syndrome of Lowe (OCRL, OMIM 309000), also known as Lowe syndrome, is a rare X-linked multisystem disorder… 
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1997
1997
Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor…
Grb2/Ash and Shc are the adapter proteins that link tyrosine-kinase receptors to Ras and make tyrosine-kinase functionally… 
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Highly Cited
1996
Highly Cited
1996
p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.
The production, survival, and function of monocytes and macrophages is regulated by the macrophage colony-stimulating factor (M… 
1990
1990
Divalent cation regulation of phosphoinositide metabolism. Naturally occurring B lymphoblasts contain a Mg2(+)-regulated phosphatidylinositol-specific phospholipase C.
Membranes isolated from normal murine B lymphocytes were found to contain a novel phosphatidylinositol (PtdIns)-specific… 
Highly Cited
1982
Highly Cited
1982
The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane.
Human erythrocyte ghosts exhibit an inositol trisphosphate phosphomonoesterase activity that rapidly converts inositol 1,4,5… 
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