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indolidan

Known as: 1,3-dihydro-3,3-dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2H-indol-2-one 
National Institutes of Health

Papers overview

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Review
2015
Review
2015
In the last few years, the pyridazine derivatives have been found to exhibit a wide range of pharmacological activities. A large… 
Highly Cited
1996
Highly Cited
1996
Prostaglandin E1 (PGE1) is often added to the donor pulmonary flush solution to enhance clinical lung preservation for… 
Highly Cited
1995
Highly Cited
1995
Previous studies have demonstrated that cGMP and cAMP reduce the endothelial permeability for fluids and macromolecules when the… 
Highly Cited
1993
Highly Cited
1993
The distribution of phosphodiesterase (PDE) activities was studied in canine cardiac microsomal fractions separated by sucrose… 
1990
1990
The voltage-gated Ca2+ current (ICa) in cardiac myocytes is regulated by cAMP-dependent phosphorylation. Although the regulation… 
1989
1989
LY186126 was found to be a potent inhibitor of type IV cyclic AMP phosphodiesterase located in the sarcoplasmic reticulum of… 
1989
1989
We have radiolabeled a structural analogue of indolidan, a potent phosphodiesterase-inhibitor cardiotonic, to permit biochemical… 
1989
1989
We previously reported the structure-activity relationships (SAR) of adibendan (1), a potent and long-acting cardiotonic. This…