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indolidan
Known as:
1,3-dihydro-3,3-dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2H-indol-2-one
National Institutes of Health
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Related topics
Related topics
3 relations
Broader (2)
Indoles
Pyridazines
Narrower (1)
LY 195115
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Pyridazinone: an important element of pharmacophore possessing broad spectrum of activity
S. Dubey
,
Pradnya A. Bhosle
Medicinal Chemistry Research
2015
Corpus ID: 13875004
In the last few years, the pyridazine derivatives have been found to exhibit a wide range of pharmacological activities. A large…
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Highly Cited
1996
Highly Cited
1996
cAMP-mediated vascular protection in an orthotopic rat lung transplant model. Insights into the mechanism of action of prostaglandin E1 to improve lung preservation.
Y. Naka
,
D. Roy
,
+4 authors
D. Pinsky
Circulation research
1996
Corpus ID: 31775972
Prostaglandin E1 (PGE1) is often added to the donor pulmonary flush solution to enhance clinical lung preservation for…
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Highly Cited
1995
Highly Cited
1995
cGMP and nitric oxide modulate thrombin-induced endothelial permeability. Regulation via different pathways in human aortic and umbilical vein endothelial cells.
R. Draijer
,
D. Atsma
,
A. Van der Laarse
,
V. V. van Hinsbergh
Circulation research
1995
Corpus ID: 32960583
Previous studies have demonstrated that cGMP and cAMP reduce the endothelial permeability for fluids and macromolecules when the…
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1995
1995
Mitogenic and antimitogenic effects of pituitary adenylate cyclase-activating polypeptide (PACAP) in adult rat chromaffin cell cultures
A. Tischler
,
J. Riseberg
,
R. Gray
Neuroscience Letters
1995
Corpus ID: 25353480
Highly Cited
1993
Highly Cited
1993
Characterization of indolidan- and rolipram-sensitive cyclic nucleotide phosphodiesterases in canine and human cardiac microsomal fractions.
C. Lugnier
,
B. Muller
,
A. Le Bec
,
C. Beaudry
,
E. Rousseau
The Journal of pharmacology and experimental…
1993
Corpus ID: 1982395
The distribution of phosphodiesterase (PDE) activities was studied in canine cardiac microsomal fractions separated by sucrose…
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1990
1990
Regulation of calcium current by low-Km cyclic AMP phosphodiesterases in cardiac cells.
R. Fischmeister
,
H. C. Hartzell
Molecular pharmacology
1990
Corpus ID: 24901204
The voltage-gated Ca2+ current (ICa) in cardiac myocytes is regulated by cAMP-dependent phosphorylation. Although the regulation…
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1989
1989
Subcellular distribution of high-affinity type IV cyclic AMP phosphodiesterase activities in rabbit ventricular myocardium: relations to post-natal maturation.
P. Kithas
,
M. Artman
,
W. Thompson
,
S. Strada
Journal of molecular and cellular cardiology
1989
Corpus ID: 24182292
1989
1989
Specific binding of [3H]LY186126, an analogue of indolidan (LY195115), to cardiac membranes enriched in sarcoplasmic reticulum vesicles.
R. Kauffman
,
B. Utterback
,
D. Robertson
Circulation research
1989
Corpus ID: 10154107
LY186126 was found to be a potent inhibitor of type IV cyclic AMP phosphodiesterase located in the sarcoplasmic reticulum of…
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1989
1989
Synthesis of a tritium-labeled indolidan analogue and its use as a radioligand for phosphodiesterase-inhibitor cardiotonic binding sites.
D. Robertson
,
J. Krushinski
,
B. Utterback
,
R. Kauffman
Journal of medicinal chemistry
1989
Corpus ID: 12534059
We have radiolabeled a structural analogue of indolidan, a potent phosphodiesterase-inhibitor cardiotonic, to permit biochemical…
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1989
1989
Nonsteroidal cardiotonics. 2. The inotropic activity of linear, tricyclic 5-6-5 fused heterocycles.
W. von der Saal
,
J. Hölck
,
W. Kampe
,
A. Mertens
,
B. Müller-Beckmann
Journal of medicinal chemistry
1989
Corpus ID: 22795902
We previously reported the structure-activity relationships (SAR) of adibendan (1), a potent and long-acting cardiotonic. This…
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