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indirubin-3'-monoxime

 
National Institutes of Health

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2 relations

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IndolesOximes

Papers overview

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2011
2011
Indirubin‐3'‐monoxime, a derivative of a chinese antileukemia medicine, inhibits angiogenesis
Although the antiangiogenic activity of indirubin‐3‐monoxime (I3M), a derivative of a Chinese anti‐leukemia medicine, has been… Expand
2010
2010
Indirubin-3'-monoxime rescues spatial memory deficits and attenuates β-amyloid-associated neuropathology in a mouse model of Alzheimer's disease
Indirubin and its derivatives have been shown to possess potent inhibitory effects on cyclin-dependent protein kinase 5 and… Expand
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Highly Cited
2010
Highly Cited
2010
Indirubin-3′-Monoxime Blocks Vascular Smooth Muscle Cell Proliferation by Inhibition of Signal Transducer and Activator of Transcription 3 Signaling and Reduces Neointima Formation In Vivo
Objective—Our goal was to examine the influence of indirubin-3′-monoxime (I3MO), a natural product–derived cyclin-dependent… Expand
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2009
2009
Indirubin-3′-monoxime inhibits β-amyloid-induced neurotoxicity in neuroblastoma SH-SY5Y cells
Increasing evidence suggests that the inappropriate activation of cyclin-dependent kinases (CDKs) could induce neuronal apoptosis… Expand
2008
2008
Critical role of Bid and Bax in indirubin-3'-monoxime-induced apoptosis in human cancer cells.
Indirubin-3'-monoxime (I3M) is a derivative of indirubin, an active component from a Chinese medicinal recipe with known anti… Expand
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Highly Cited
2007
Highly Cited
2007
Efficacy of small‐molecule glycogen synthase kinase‐3 inhibitors in the postnatal rat model of tau hyperphosphorylation
Glycogen synthase kinase‐3 (GSK‐3) affects neuropathological events associated with Alzheimeŕs disease (AD) such as… Expand
Highly Cited
2007
Highly Cited
2007
Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish.
Pathologic angiogenesis has emerged as an important therapeutic target in several major diseases. Zebrafish offer the potential… Expand
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Highly Cited
2005
Highly Cited
2005
Indirubin-3′-monoxime, a derivative of a Chinese antileukemia medicine, inhibits P-TEFb function and HIV-1 replication
Objective:To evaluate the effects of the cyclin dependent kinase (CDK) inhibitor Indirubin-3′-monoxime (IM) on Tat-mediated… Expand
Highly Cited
2003
Highly Cited
2003
The specificities of protein kinase inhibitors: an update.
We have previously examined the specificities of 28 commercially available compounds, reported to be relatively selective… Expand
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Highly Cited
2001
Highly Cited
2001
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase…
The bis-indole indirubin is an active ingredient of Danggui Longhui Wan, a traditional Chinese medicine recipe used in the… Expand
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