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indirubin-3'-monoxime

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2001-2017
02420012017

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2 relations

Broader (2)

IndolesOximes

Related mentions per year

Related mentions per year

1939-2018
19401960198020002020
indirubin-3'-monoxime
Oximes
Indoles

Papers overview

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2014
2014
Indirubin-3′-monoxime exerts a dual mode of inhibition towards leukotriene-mediated vascular smooth muscle cell migration
AIMS The small molecule indirubin-3'-monoxime (I3MO) has been shown to inhibit vascular smooth muscle cell (VSMC) proliferation… (More)
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2014
2014
Antiplatelet action of indirubin-3'-monoxime through suppression of glycoprotein VI-mediated signal transduction: a possible role for ERK signaling in platelets.
We investigated the antiplatelet activity of indirubin-3'-monoxime (I3O) and the underlying mechanisms. In a rat carotid artery… (More)
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2011
2011
Antiproliferative and apoptosis inducing effects of indirubin-3'-monoxime in renal cell cancer cells.
OBJECTIVES Indirubin-3'-monoxime, which is a selective and potent inhibitor of cyclin-dependent kinases (CDKs) has shown… (More)
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2010
2010
Indirubin-3'-monoxime rescues spatial memory deficits and attenuates beta-amyloid-associated neuropathology in a mouse model of Alzheimer's disease.
Indirubin and its derivatives have been shown to possess potent inhibitory effects on cyclin-dependent protein kinase 5 and… (More)
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2010
2010
Indirubin-3'-monoxime blocks vascular smooth muscle cell proliferation by inhibition of signal transducer and activator of transcription 3 signaling and reduces neointima formation in vivo.
OBJECTIVE Our goal was to examine the influence of indirubin-3'-monoxime (I3MO), a natural product-derived cyclin-dependent… (More)
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2008
2008
Critical role of Bid and Bax in indirubin-3'-monoxime-induced apoptosis in human cancer cells.
Indirubin-3'-monoxime (I3M) is a derivative of indirubin, an active component from a Chinese medicinal recipe with known anti… (More)
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2008
2008
Indirubin-3'-monoxime, a derivative of a Chinese anti-leukemia medicine, inhibits Notch1 signaling.
Notch proteins perform a critical function in cell-fate decisions and in differentiation. In this study, we determined that… (More)
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Highly Cited
2007
Highly Cited
2007
Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish.
Pathologic angiogenesis has emerged as an important therapeutic target in several major diseases. Zebrafish offer the potential… (More)
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2006
2006
Indirubin-3'-monoxime, a CDK inhibitor induces growth inhibition and apoptosis-independent up-regulation of survivin in transitional cell cancer.
In traditional Chinese Medicine, the preparation Danggui Longhui Wan has been used for years in the treatment of chronic… (More)
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2001
2001
Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells
The bisindole indirubin has been described, more than 30 years ago, as being clinically active in the treatment of human chronic… (More)
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