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indirubin-3'-monoxime

 
National Institutes of Health

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IndolesOximes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Neuroprotective role of Indirubin-3'-monoxime, a GSKβ inhibitor in high fat diet induced cognitive impairment in mice.
Recent studies have highlighted that diabetes mellitus (DM) is a strong risk factor for Alzheimer's disease (AD). Insulin… Expand
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2010
2010
Indirubin-3'-monoxime rescues spatial memory deficits and attenuates β-amyloid-associated neuropathology in a mouse model of Alzheimer's disease
Indirubin and its derivatives have been shown to possess potent inhibitory effects on cyclin-dependent protein kinase 5 and… Expand
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2010
2010
Indirubin-3'-monoxime blocks vascular smooth muscle cell proliferation by inhibition of signal transducer and activator of transcription 3 signaling and reduces neointima formation in vivo.
OBJECTIVE Our goal was to examine the influence of indirubin-3'-monoxime (I3MO), a natural product-derived cyclin-dependent… Expand
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2009
2009
Indirubin-3′-monoxime inhibits β-amyloid-induced neurotoxicity in neuroblastoma SH-SY5Y cells
Increasing evidence suggests that the inappropriate activation of cyclin-dependent kinases (CDKs) could induce neuronal apoptosis… Expand
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2008
2008
Indirubin-3'-monoxime, a derivative of a Chinese anti-leukemia medicine, inhibits Notch1 signaling.
Notch proteins perform a critical function in cell-fate decisions and in differentiation. In this study, we determined that… Expand
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Highly Cited
2007
Highly Cited
2007
Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish.
Pathologic angiogenesis has emerged as an important therapeutic target in several major diseases. Zebrafish offer the potential… Expand
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2006
2006
Indirubin-3'-monoxime, a CDK inhibitor induces growth inhibition and apoptosis-independent up-regulation of survivin in transitional cell cancer.
In traditional Chinese Medicine, the preparation Danggui Longhui Wan has been used for years in the treatment of chronic… Expand
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2005
2005
Indirubin-3'-monoxime, a derivative of a Chinese antileukemia medicine, inhibits P-TEFb function and HIV-1 replication.
OBJECTIVE To evaluate the effects of the cyclin dependent kinase (CDK) inhibitor Indirubin-3'-monoxime (IM) on Tat-mediated… Expand
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Highly Cited
2003
Highly Cited
2003
The specificities of protein kinase inhibitors: an update.
We have previously examined the specificities of 28 commercially available compounds, reported to be relatively selective… Expand
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Highly Cited
2001
Highly Cited
2001
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase…
The bis-indole indirubin is an active ingredient of Danggui Longhui Wan, a traditional Chinese medicine recipe used in the… Expand
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