immunophilin activity

Known as: immunophilin 
OBSOLETE. Any member of a family of receptors that includes the major FK506 binding protein FKBP and cyclophilin. These two proteins are unrelated in… (More)
National Institutes of Health

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Highly Cited
2004
Highly Cited
2004
The tumor suppressor protein p53 is known to be transported to the nucleus along microtubular tracks by cytoplasmic dynein… (More)
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Highly Cited
2002
Highly Cited
2002
We have identified a new first step in the hormonal activation of the glucocorticoid receptor (GR). Rather than causing immediate… (More)
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Highly Cited
2000
Highly Cited
2000
Squirrel monkeys have high circulating cortisol to compensate for expression of low-affinity glucocorticoid receptors (GRs). We… (More)
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Highly Cited
1997
Highly Cited
1997
Steroid receptors are recovered from hormone-free cells in multiprotein complexes containing hsp90, p23, an immunophilin, and… (More)
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Highly Cited
1996
Highly Cited
1996
The immunophilin FKBP12 is an evolutionarily conserved abundant protein; however, its physiological roles remain poorly defined… (More)
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Highly Cited
1995
Highly Cited
1995
The immunophilin FK506 binding protein 12 (FKBP12) is associated with and modulates the ryanodine receptor calcium release… (More)
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Highly Cited
1995
Highly Cited
1995
The immunosuppressive drugs FK506 and cyclosporin A block T-lymphocyte proliferation by inhibiting calcineurin, a critical… (More)
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Highly Cited
1994
Highly Cited
1994
THE immunosuppressive action of the drug FK506 involves inhibition of calcineurin in T-lymphocytes by a complex of FK506 and an… (More)
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Highly Cited
1994
Highly Cited
1994
Transforming growth factor-beta (TGF-beta) family members bind to receptors that consist of heteromeric serine-threonine kinase… (More)
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Highly Cited
1990
Highly Cited
1990
Proliferation and immunologic function of T lymphocytes are initiated by signals from the antigen receptor that are inhibited by… (More)
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