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Several anti-inflammatory agents based on pyrazole and imidazopyrazole scaffolds and a large library of substituted catechol… Expand Even though immunotherapy has radically changed the search for anticancer therapies, there are still many different pathways that… Expand Taking into account the structure activity relationship information given by our previous studies, we designed and synthesized a… Expand The efficient, facile and green synthesis of 4-bromo pyrazolone by using N-bromo saccharine as valuable green reagent encouraged… Expand Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA
The receptor tyrosine kinase Tie2 is predominantly… Expand On the basis of structures of known topoisomerase II catalytic inhibitors and initial molecular docking studies, bicyclic N-fused… Expand The compounds of formula (I) shown below and a preparation method thereof can be applied in pharmaceutically acceptable salt… Expand A sensitive, specific GC assay for imidazopyrazole in plasma was developed using nitrogen-specific detection. The samples are… Expand Plasma decay kinetics were analyzed for seven patients (400-5700 mg) during a Phase I clinical trial of imidazopyrazole. A two… Expand