imidazole mustard

Known as: BIC mustard, 5-[3, 3-Bis(2-chloroethyl)-1-triazeno]imidazole-4-carboxamide, HN2 
A synthetic derivative of imidazole with potent antineoplastic properties. Imidazole mustard alkylates DNA, preferentially at guanine residues… (More)

Topic mentions per year

Topic mentions per year

1946-2017
05010019462016

Papers overview

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Highly Cited
2010
Highly Cited
2010
Array processing is widely used in sensing applications for estimating the locations and waveforms of the sources in a given… (More)
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Highly Cited
2006
Highly Cited
2006
MicroRNAs (miRNAs) represent a newly discovered class of posttranscriptional regulatory noncoding small RNAs that bind to… (More)
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Highly Cited
2006
Highly Cited
2006
Let Y be a Gaussian vector whose components are independent with a common unknown variance. We consider the problem of estimating… (More)
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Highly Cited
2006
Highly Cited
2006
Vector-based RNA interference (RNAi) has emerged as a valuable tool for analysis of gene function. We have developed new RNA… (More)
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Highly Cited
2005
Highly Cited
2005
We show that the microRNA miR-155 can be processed from sequences present in BIC RNA, a spliced and polyadenylated but non… (More)
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Highly Cited
2005
Highly Cited
2005
In a previous study we demonstrated high expression of the non-coding BIC gene in the vast majority of Hodgkin's lymphomas (HLs… (More)
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Highly Cited
2003
Highly Cited
2003
It is well known that AIC and BIC have different properties in model selection. BIC is consistent in the sense that if the true… (More)
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Highly Cited
2000
Highly Cited
2000
The mechanisms by which DNA interstrand cross-links (ICLs) are repaired in mammalian cells are unclear. Studies in bacteria and… (More)
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Highly Cited
1982
Highly Cited
1982
Caffeine is synergistic with many DNA-damaging agents in increasing lethality to mammalian cells. The mechanism is not well… (More)
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Highly Cited
1979
Highly Cited
1979
The effects of an inhibitor of GABA synthesis, 3-mercaptopropionic acid (MP), and of the GABA antagonist bicuculline (BIC), on… (More)
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