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imidazole mustard

Known as: BIC mustard, 5-[3, 3-Bis(2-chloroethyl)-1-triazeno]imidazole-4-carboxamide, HN2 
A synthetic derivative of imidazole with potent antineoplastic properties. Imidazole mustard alkylates DNA, preferentially at guanine residues… 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (2)

Imidazole CarboxamideNitrogen Mustard Compounds
MechlorethamineMechlorethamine hydrochlorideNCIt Antineoplastic Agent Terminology

Narrower (1)

NSC-82196

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Comparison between Bicarbonate/Lactate and Standard Lactate Dialysis Solution in Peritoneal Transport and Ultrafiltration: A Prospective, Crossover Single-Dwell Study
Objective It has been proposed that biocompatible bicarbonate/lactate based (Bic/Lac), physiologic-pH peritoneal dialysis (PD… 
Highly Cited
2005
Highly Cited
2005
Roles of inhibition in creating complex auditory responses in the inferior colliculus: facilitated combination-sensitive neurons.
We studied roles of inhibition on temporally sensitive facilitation in combination-sensitive neurons from the mustached bat's… 
Highly Cited
2000
Highly Cited
2000
Efficient protection of human bronchial epithelial cells against sulfur and nitrogen mustard cytotoxicity using drug combinations.
The aim of this study was to test the efficacy of several candidate molecules against sulfur mustard (SM) and nitrogen mustard… 
1990
1990
DNA adenine adducts induced by nitrogen mustards and their role in transcription termination in vitro.
Previous studies have demonstrated that three cancer chemotherapeutic compounds of the nitrogen mustard class, melphalan (L-PAM… 
Highly Cited
1979
Highly Cited
1979
Mutagen-sensitive mutants in Drosophila melanogaster: effects on premutational damage.
Review
1976
Review
1976
Single-agent chemotherapy of brain tumors. A five-year review.
Identification of effective single chemotherapeutic agents for brain tumors must precede the rational use of multiple drug… 
Highly Cited
1974
Highly Cited
1974
Lack of chemically induced mutation in repair-deficient mutants of yeast.
Two genes, rad6 and rad9, that confer radiation sensitivity in the yeast Saccharomyces cerevisiae also greatly reduce the… 
Highly Cited
1970
Highly Cited
1970
Evidence for a transport carrier of nitrogen mustard in nitrogen mustard-sensitive and -resistant L5178Y lymphoblasts.
Summary Uptake of nitrogen mustard (HN2)- 14 C by HN2-sensitive and -resistant L5178Y lymphoblasts followed simple Michaelis… 
Highly Cited
1965
Highly Cited
1965
REPAIR REPLICATION OF DNA IN BACTERIA: IRRELEVANCE OF CHEMICAL NATURE OF BASE DEFECT.
Highly Cited
1961
Highly Cited
1961
Differences in the response of leukaemia cells in tissue culture to nitrogen mustard and to dimethyl myleran.
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