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ibodutant

Known as: benzo(b)thiophene-2-carboxamide, 6-methyl-N-(1-((((1R)-2- oxo-1-(phenylmethyl)-2-(((1-((tetrahydro-2H-pyran-4- yl)methyl)-4- piperidinyl)methyl)amino)ethyl)amino)carbonyl)cyclopentyl)- 
 
National Institutes of Health

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2 relations

Broader (2)

DipeptidesThiophenes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
The neurokinin-2 receptor antagonist ibodutant improves overall symptoms, abdominal pain and stool pattern in female patients in a phase II study of diarrhoea-predominant IBS
Background Tachykinins have been implicated in the pathophysiology of IBS with diarrhoea (IBS-D). Our aim was to study the… Expand
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2016
2016
Gender-related differential effect of tachykinin NK2 receptor-mediated visceral hyperalgesia in guinea pig colon.
BACKGROUND AND PURPOSE The tachykinin NK2 receptor antagonist ibodutant is under Phase III clinical investigation to treat female… Expand
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2013
2013
Characterization of ibodutant at NK(2) receptor in human colon.
We have characterized the pharmacological profile of the nonpeptide tachykinin NK2 receptor antagonist ibodutant (MEN15596… Expand
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2013
2013
Antagonist profile of ibodutant at the tachykinin NK2 receptor in guinea pig isolated bronchi.
In this study we have characterized the pharmacological profile of the non-peptide tachykinin NK2 receptor antagonist ibodutant… Expand
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2013
2013
Peristalsis and propulsion of colonic content can occur after blockade of major neuroneuronal and neuromuscular transmitters in isolated guinea pig colon.
We recently identified hexamethonium-resistant peristalsis in the guinea pig colon. We showed that, following acute blockade of… Expand
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2013
2013
Antagonist profile of ibodutant at the tachykinin NK(2) receptor in guinea pig isolated bronchi.
In this study we have characterized the pharmacological profile of the non-peptide tachykinin NK(2) receptor antagonist ibodutant… Expand
Is this relevant?
2013
2013
520 Efficacy of Ibodutant, a Selective Antagonist of Neurokinin 2 Receptors, in Irritable Bowel Syndrome With Diarrhoea (IBS-D): The Results of a Double-Blind, Randomised, Placebo-Controlled…
 
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2011
2011
Effect of otilonium bromide and ibodutant on the internalization of the NK2 receptor in human colon.
BACKGROUND The present aim was to study the modulation of NK2 receptor internalization by two compounds, the spasmolytic… Expand
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2009
2009
Multifaceted approach to determine the antagonist molecular mechanism and interaction of ibodutant ([1-(2-phenyl-1R-[[1-(tetrahydropyran-4-ylmethyl)-piperidin-4-ylmethyl]-carbamoyl]-ethylcarbamoyl…
Ibodutant (MEN15596, [1-(2-phenyl-1R-[[1-(tetrahydropyran-4-ylmethyl)-piperidin-4-ylmethyl]-carbamoyl]-ethylcarbamoyl… Expand
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1992
1992
Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors.
Investigation of the SAR of the lead (methoxyalkyl)thiazole 1-[3-(naphth-2-ylmethoxy)phenyl]-1-thiazol-2-ylprop yl methyl ether… Expand
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