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ibodutant

Known as: benzo(b)thiophene-2-carboxamide, 6-methyl-N-(1-((((1R)-2- oxo-1-(phenylmethyl)-2-(((1-((tetrahydro-2H-pyran-4- yl)methyl)-4- piperidinyl)methyl)amino)ethyl)amino)carbonyl)cyclopentyl)- 
National Institutes of Health

Papers overview

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2016
2016
Background Tachykinins have been implicated in the pathophysiology of IBS with diarrhoea (IBS-D). Our aim was to study the… 
2016
2016
The tachykinin NK2 receptor antagonist ibodutant is under Phase III clinical investigation to treat female patients with… 
2014
2014
Small D-π-A type organic molecules with incorporated 4H-pyan-4-ylidene (pyranylidene) fragment in their structures show potential… 
2013
2013
2013
2013
We recently identified hexamethonium-resistant peristalsis in the guinea pig colon. We showed that, following acute blockade of… 
2013
2013
In this study we have characterized the pharmacological profile of the non-peptide tachykinin NK(2) receptor antagonist ibodutant… 
2011
2011
Background  The present aim was to study the modulation of NK2 receptor internalization by two compounds, the spasmolytic… 
2009
2009
Ibodutant (MEN15596, [1-(2-phenyl-1R-{[1-(tetrahydropyran-4-ylmethyl)-piperidin-4-ylmethyl]-carbamoyl}-ethylcarbamoyl… 
Highly Cited
1992
Highly Cited
1992
Investigation of the SAR of the lead (methoxyalkyl)thiazole 1-[3-(naphth-2-ylmethoxy)phenyl]-1-thiazol-2-ylprop yl methyl ether…