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ibodutant
Known as:
benzo(b)thiophene-2-carboxamide, 6-methyl-N-(1-((((1R)-2- oxo-1-(phenylmethyl)-2-(((1-((tetrahydro-2H-pyran-4- yl)methyl)-4- piperidinyl)methyl)amino)ethyl)amino)carbonyl)cyclopentyl)-
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Dipeptides
Thiophenes
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
The neurokinin-2 receptor antagonist ibodutant improves overall symptoms, abdominal pain and stool pattern in female patients in a phase II study of diarrhoea-predominant IBS
J. Tack
,
K. Schumacher
,
G. Tonini
,
S. Scartoni
,
A. Capriati
,
C. Maggi
Gut
2016
Corpus ID: 3465599
Background Tachykinins have been implicated in the pathophysiology of IBS with diarrhoea (IBS-D). Our aim was to study the…
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2016
2016
Gender‐related differential effect of tachykinin NK2 receptor‐mediated visceral hyperalgesia in guinea pig colon
F. Bellucci
,
L. Buéno
,
+6 authors
C. Maggi
British journal of pharmacology
2016
Corpus ID: 24074251
The tachykinin NK2 receptor antagonist ibodutant is under Phase III clinical investigation to treat female patients with…
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2014
2014
Thermal and optical properties of 4H-pyran-4-ylidene fragment and bis-styryl and triphenyl groups containing derivatives
E. Zarins
,
A. Vembris
,
V. Kokars
,
M. Rutkis
Other Conferences
2014
Corpus ID: 135962246
Small D-π-A type organic molecules with incorporated 4H-pyan-4-ylidene (pyranylidene) fragment in their structures show potential…
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2013
2013
520 Efficacy of Ibodutant, a Selective Antagonist of Neurokinin 2 Receptors, in Irritable Bowel Syndrome With Diarrhoea (IBS-D): The Results of a Double-Blind, Randomised, Placebo-Controlled…
J. Tack
,
Yavor S. Dochev
,
+7 authors
C. Maggi
2013
Corpus ID: 74378079
2013
2013
Characterization of ibodutant at NK(2) receptor in human colon.
P. Santicioli
,
S. Meini
,
+5 authors
C. Maggi
European journal of pharmacology
2013
Corpus ID: 39262948
2013
2013
Peristalsis and propulsion of colonic content can occur after blockade of major neuroneuronal and neuromuscular transmitters in isolated guinea pig colon.
T. Sia
,
S. Brookes
,
P. Dinning
,
D. Wattchow
,
N. Spencer
American journal of physiology. Gastrointestinal…
2013
Corpus ID: 1908079
We recently identified hexamethonium-resistant peristalsis in the guinea pig colon. We showed that, following acute blockade of…
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2013
2013
Antagonist profile of ibodutant at the tachykinin NK(2) receptor in guinea pig isolated bronchi.
P. Santicioli
,
S. Meini
,
S. Giuliani
,
A. Lecci
,
C. Maggi
European journal of pharmacology
2013
Corpus ID: 4550372
In this study we have characterized the pharmacological profile of the non-peptide tachykinin NK(2) receptor antagonist ibodutant…
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2011
2011
Effect of otilonium bromide and ibodutant on the internalization of the NK2 receptor in human colon
G. Cipriani
,
P. Santicioli
,
+6 authors
M. Vannucchi
Neurogastroenterology and motility : the official…
2011
Corpus ID: 26044097
Background The present aim was to study the modulation of NK2 receptor internalization by two compounds, the spasmolytic…
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2009
2009
Multifaceted Approach to Determine the Antagonist Molecular Mechanism and Interaction of Ibodutant ([1-(2-Phenyl-1R-{[1-(tetrahydropyran-4-ylmethyl)-piperidin-4-ylmethyl]-carbamoyl}-ethylcarbamoyl…
S. Meini
,
F. Bellucci
,
+4 authors
S. Giuliani
Journal of Pharmacology and Experimental…
2009
Corpus ID: 8363056
Ibodutant (MEN15596, [1-(2-phenyl-1R-{[1-(tetrahydropyran-4-ylmethyl)-piperidin-4-ylmethyl]-carbamoyl}-ethylcarbamoyl…
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Highly Cited
1992
Highly Cited
1992
Methoxytetrahydropyrans. A new series of selective and orally potent 5-lipoxygenase inhibitors.
G. C. Crawley
,
R. Dowell
,
+7 authors
J. M. Giroaeau
Journal of medicinal chemistry
1992
Corpus ID: 61855
Investigation of the SAR of the lead (methoxyalkyl)thiazole 1-[3-(naphth-2-ylmethoxy)phenyl]-1-thiazol-2-ylprop yl methyl ether…
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