hypermethylation of CpG island

Known as: DNA hypermethylation of CpG island 
An increase in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a… (More)
National Institutes of Health

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Highly Cited
2011
Highly Cited
2011
Cancer cells simultaneously harbor global losses and gains in DNA methylation. We demonstrate that inducing cellular oxidative… (More)
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Highly Cited
2009
Highly Cited
2009
Epigenetic control of gene transcription is critical for normal human development and cellular differentiation. While alterations… (More)
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Highly Cited
2009
Highly Cited
2009
CpG island promoter methylation of tumor suppressor genes is one of the most characteristic abnormalities in EBV-associated… (More)
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Highly Cited
2004
Highly Cited
2004
The aim of this study was to test the hypothesis that mutations of the oncogenes BRAF or KRAS are early events in the putative… (More)
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Highly Cited
2002
Highly Cited
2002
CpG island methylation is an important mechanism for inactivating the genes involved in tumorigenesis. Gastric carcinoma (GC) is… (More)
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Highly Cited
2001
Highly Cited
2001
The human Ras association domain family 1A gene (RASSF1A), recently cloned from the lung tumor suppressor locus 3p21.3, was shown… (More)
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Highly Cited
1999
Highly Cited
1999
The DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) removes alkyl adducts from the O6 position of guanine. MGMT… (More)
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Highly Cited
1999
Highly Cited
1999
The DNA repair protein O-methylguanine DNA methyltransferase (MGMT) removes alkyl adducts from the O position of guanine. MGMT… (More)
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Highly Cited
1997
Highly Cited
1992
Highly Cited
1992
CpG islands are short, dispersed regions of unmethylated DNA with a high frequency of CpG dinucleotides relative to the bulk… (More)
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