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hypermethylation of CpG island

Known as: DNA hypermethylation of CpG island 
An increase in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Colorectal cancer (CRC) is a major cause of cancer death worldwide. CRC has poor prognosis and there is a crucial need for new… Expand
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Highly Cited
2014
Highly Cited
2014
In mammals, cytosine methylation is predominantly restricted to CpG dinucleotides and stably distributed across the genome, with… Expand
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Highly Cited
2011
Highly Cited
2011
Cancer cells simultaneously harbor global losses and gains in DNA methylation. We demonstrate that inducing cellular oxidative… Expand
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Highly Cited
2009
Highly Cited
2009
Epigenetic control of gene transcription is critical for normal human development and cellular differentiation. While alterations… Expand
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Highly Cited
2007
Highly Cited
2007
Colon cancer has been viewed as the result of progressive accumulation of genetic and epigenetic abnormalities. However, this… Expand
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Highly Cited
2003
Highly Cited
2003
Somatic inactivation of the glutathione S-transferase-pi gene (GSTP1) via CpG island hypermethylation occurs early during… Expand
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Highly Cited
2002
Highly Cited
2002
CpG island methylation is an important mechanism for inactivating the genes involved in tumorigenesis. Gastric carcinoma (GC) is… Expand
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Highly Cited
2001
Highly Cited
2001
The human Ras association domain family 1A gene (RASSF1A), recently cloned from the lung tumor suppressor locus 3p21.3, was shown… Expand
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Highly Cited
1999
Highly Cited
1999
The DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) removes alkyl adducts from the O6 position of guanine. MGMT… Expand
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Highly Cited
1997
Highly Cited
1997
Promoter region CpG island methylation is associated with tumor suppressor gene silencing in neoplasia. GenBank sequence analyses… Expand
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