hymecromone O,O-diethyl phosphorothioate
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Cardiovascular disease remains the leading cause of mortality in westernized countries, despite optimum medical therapy to reduce… Expand Current understanding of microRNA (miRNA) biology is limited, and antisense oligonucleotide (ASO) inhibition of miRNAs is a… Expand There has been steady progress in antisense technology over the past 14 years. We now have a far better appreciation of the… Expand The development of nucleoside phosphorothioates is described in its historical context. Examples of the interaction of… Expand The hairpin ribozyme is an example of a small catalytic RNA which catalyses the endonucleolytic transesterification of RNA in a… Expand Diseases characterized by retinal neovascularization are among the principal causes of visual loss worldwide. The hypoxia… Expand A phosphorothioate‐oligonucleotide‐based antisense strategy for depleting MAP kinase was developed. The 17mer antisense probe… Expand In response to inflammatory stimuli, expression of a group of proteins that bind circulating leukocytes (endothelial-leukocyte… Expand "Uniformly" modified phosphodiester or phosphorothioate oligonucleotides incorporating 2'-deoxy-2'-fluoroadenosine, -guanosine… Expand Alteration of gene transcription by inhibition of specific transcriptional regulatory proteins is necessary for determining how… Expand